(1R,2R,4R)-4-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)quinolin-4-yloxy]cyclohexane-1,2-dicarboxylic acid 2-benzyl ester

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Chemical Name:(1R,2R,4R)-4-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)quinolin-4-yloxy]cyclohexane-1,2-dicarboxylic acid 2-benzyl ester
CAS No.:1265882-92-5
Molecular Formula:C₃₀H₂₇F₃N₂O₆S
Molecular Weight:600.615
Hs Code.:

Synonyms:(1R,2R,4R)-4-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)quinolin-4-yloxy]cyclohexane-1,2-dicarboxylic acid 2-benzyl ester

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Chemical Property of (1R,2R,4R)-4-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)quinolin-4-yloxy]cyclohexane-1,2-dicarboxylic acid 2-benzyl ester

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Technology Process of (1R,2R,4R)-4-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)quinolin-4-yloxy]cyclohexane-1,2-dicarboxylic acid 2-benzyl ester

There total 10 articles about (1R,2R,4R)-4-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)quinolin-4-yloxy]cyclohexane-1,2-dicarboxylic acid 2-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1265882-91-4
(1R,2R,4R)-4-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)-quinolin-4-yloxy]cyclohexane-1,2-dicarboxylic acid 2-benzyl ester 1-methyl ester

: 1265882-92-5
(1R,2R,4R)-4-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)quinolin-4-yloxy]cyclohexane-1,2-dicarboxylic acid 2-benzyl ester

Guidance literature:: (1R,2R,4R)-4-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)-quinolin-4-yloxy]cyclohexane-1,2-dicarboxylic acid 2-benzyl ester 1-methyl ester; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; water; pH=2;

Reference yield:

: 31139-02-3,31139-03-4,56124-48-2,88335-93-7,88335-94-8,93603-11-3
(1R,6S)-6-methoxycarbonyl-3-cyclohexene-1-carboxylic acid

: 1265882-92-5
(1R,2R,4R)-4-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)quinolin-4-yloxy]cyclohexane-1,2-dicarboxylic acid 2-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

1.2: pH 1

2.1: potassium iodide; sodium hydrogencarbonate; iodine / dichloromethane; water / 48 h

3.1: tris-(trimethylsilyl)silane / 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / 90 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / Inert atmosphere

5.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

6.1: lithium hydroxide / water; tetrahydrofuran / 4 h / 20 °C

6.2: pH 2

With di-isopropyl azodicarboxylate; tris-(trimethylsilyl)silane; potassium tert-butylate; iodine; sodium hydrogencarbonate; potassium carbonate; potassium iodide; lithium hydroxide; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 912347-94-5
1-(2-amino-4-methoxy-3-methyl-phenyl)ethanone

: 1265882-92-5
(1R,2R,4R)-4-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)quinolin-4-yloxy]cyclohexane-1,2-dicarboxylic acid 2-benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: potassium tert-butylate / tert-butyl alcohol / 16 h / 70 °C / Inert atmosphere

3.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

4.1: lithium hydroxide / water; tetrahydrofuran / 4 h / 20 °C

4.2: pH 2

With oxalyl dichloride; di-isopropyl azodicarboxylate; potassium tert-butylate; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;