(S)-2-{(S)-2-[(2-Amino-acetyl)-(2-benzyloxycarbonylamino-2-methyl-propyl)-amino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

Base Information

Chemical Name:(S)-2-{(S)-2-[(2-Amino-acetyl)-(2-benzyloxycarbonylamino-2-methyl-propyl)-amino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester
CAS No.:150391-13-2
Molecular Formula:C₃₀H₄₂N₄O₆
Molecular Weight:554.687
Hs Code.:

Synonyms:(S)-2-{(S)-2-[(2-Amino-acetyl)-(2-benzyloxycarbonylamino-2-methyl-propyl)-amino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-{(S)-2-[(2-Amino-acetyl)-(2-benzyloxycarbonylamino-2-methyl-propyl)-amino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-{(S)-2-[(2-Amino-acetyl)-(2-benzyloxycarbonylamino-2-methyl-propyl)-amino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

There total 5 articles about (S)-2-{(S)-2-[(2-Amino-acetyl)-(2-benzyloxycarbonylamino-2-methyl-propyl)-amino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 150391-26-7
(S)-2-((S)-2-{(2-Benzyloxycarbonylamino-2-methyl-propyl)-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetyl]-amino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid methyl ester

: 150391-13-2
(S)-2-{(S)-2-[(2-Amino-acetyl)-(2-benzyloxycarbonylamino-2-methyl-propyl)-amino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

Guidance literature:: With diethylamine; In acetonitrile; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(01)90205-4

Reference yield:

: 62471-40-3
2-benzyloxycarbonylamino-2-methylpropanol

: 150391-13-2
(S)-2-{(S)-2-[(2-Amino-acetyl)-(2-benzyloxycarbonylamino-2-methyl-propyl)-amino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: PDC, MS 4A / CH₂Cl₂ / Ambient temperature

2: 81 percent / NaBH(OAc)3 / tetrahydrofuran / Ambient temperature

3: AgCN / benzene / 12 h / Ambient temperature

4: 51 percent / Et₂NH / acetonitrile / 1 h / Ambient temperature

With dipyridinium dichromate; silver cyanide; sodium tris(acetoxy)borohydride; diethylamine; In tetrahydrofuran; dichloromethane; acetonitrile; benzene;
DOI:10.1016/S0040-4020(01)90205-4

Reference yield:

: 114856-91-6
benzyl (2-methyl-1-oxopropan-2-yl)carbamate

: 150391-13-2
(S)-2-{(S)-2-[(2-Amino-acetyl)-(2-benzyloxycarbonylamino-2-methyl-propyl)-amino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / NaBH(OAc)3 / tetrahydrofuran / Ambient temperature

2: AgCN / benzene / 12 h / Ambient temperature

3: 51 percent / Et₂NH / acetonitrile / 1 h / Ambient temperature

With silver cyanide; sodium tris(acetoxy)borohydride; diethylamine; In tetrahydrofuran; acetonitrile; benzene;
DOI:10.1016/S0040-4020(01)90205-4