(1S,2S,3R,4R,5R)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-5-(3-nitrophenethylamino)bicyclo[2.2.1]heptane-2-carboxamide

Base Information

Chemical Name:(1S,2S,3R,4R,5R)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-5-(3-nitrophenethylamino)bicyclo[2.2.1]heptane-2-carboxamide
CAS No.:1214924-42-1
Molecular Formula:C₂₀H₂₂ClFN₆O₃
Molecular Weight:448.884
Hs Code.:

Synonyms:(1S,2S,3R,4R,5R)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-5-(3-nitrophenethylamino)bicyclo[2.2.1]heptane-2-carboxamide

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S,3R,4R,5R)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-5-(3-nitrophenethylamino)bicyclo[2.2.1]heptane-2-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (1S,2S,3R,4R,5R)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-5-(3-nitrophenethylamino)bicyclo[2.2.1]heptane-2-carboxamide

There total 3 articles about (1S,2S,3R,4R,5R)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-5-(3-nitrophenethylamino)bicyclo[2.2.1]heptane-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1214924-15-8
(1S,2S,3R,4R,5R)-5-amino-3-(2-chloro-5-fluoropyrimidin-4-ylamino)bicyclo[2.2.1]heptane-2-carboxamide

: 69628-97-3
toluene-4-sulfonic acid 2-(3-nitrophenyl)ethyl ester

: 1214924-42-1
(1S,2S,3R,4R,5R)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-5-(3-nitrophenethylamino)bicyclo[2.2.1]heptane-2-carboxamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; sealed tube;

Reference yield:

: 1214924-13-6
(1S,2S,3R,4S,5R)-5-azido-3-(2-chloro-5-fluoropyrimidin-4-ylamino)bicyclo[2.2.1]heptane-2-carboxamide

: 1214924-42-1
(1S,2S,3R,4R,5R)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-5-(3-nitrophenethylamino)bicyclo[2.2.1]heptane-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; water / tetrahydrofuran / 48 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 20 °C / sealed tube

With water; caesium carbonate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 52022-77-2
2-(3-nitrophenyl)ethanol

: 1214924-42-1
(1S,2S,3R,4R,5R)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-5-(3-nitrophenethylamino)bicyclo[2.2.1]heptane-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 20 °C / sealed tube

With pyridine; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;