benzyl (2S,4R)-N-BOC-4-(prop-2-ynyl)pyroglutamate

Base Information

Chemical Name:benzyl (2S,4R)-N-BOC-4-(prop-2-ynyl)pyroglutamate
CAS No.:204066-65-9
Molecular Formula:C₂₀H₂₃NO₅
Molecular Weight:357.406
Hs Code.:

Synonyms:benzyl (2S,4R)-N-BOC-4-(prop-2-ynyl)pyroglutamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (2S,4R)-N-BOC-4-(prop-2-ynyl)pyroglutamate

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Technology Process of benzyl (2S,4R)-N-BOC-4-(prop-2-ynyl)pyroglutamate

There total 1 articles about benzyl (2S,4R)-N-BOC-4-(prop-2-ynyl)pyroglutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 113400-36-5,400626-71-3
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

: 106-96-7
propargyl bromide

: 204066-65-9
benzyl (2S,4R)-N-BOC-4-(prop-2-ynyl)pyroglutamate

: benzyl (2S,4S)-N-Boc-4-(prop-2-ynyl)pyroglutamate

Guidance literature:: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

propargyl bromide; In tetrahydrofuran; at -78 ℃; for 2h; Further stages.;
DOI:10.1021/jm9911682

Reference yield: 82.0%

: 591-50-4
iodobenzene

: 204066-65-9
benzyl (2S,4R)-N-BOC-4-(prop-2-ynyl)pyroglutamate

: 284024-87-9
benzyl (2S,4R)-N-BOC-4-(3-phenylprop-2-ynyl)pyroglutamate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 70 ℃; for 2.5h;
DOI:10.1021/jm9911682