(6R,7R)-7-(2-tert-Butoxycarbonylamino-2-phenyl-acetylamino)-8-oxo-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Base Information

Chemical Name:(6R,7R)-7-(2-tert-Butoxycarbonylamino-2-phenyl-acetylamino)-8-oxo-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
CAS No.:1061680-00-9
Molecular Formula:C₅₅H₅₀N₆O₆S₃
Molecular Weight:987.237
Hs Code.:

(6R,7R)-7-(2-tert-Butoxycarbonylamino-2-phenyl-acetylamino)-8-oxo-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Synonyms:(6R,7R)-7-(2-tert-Butoxycarbonylamino-2-phenyl-acetylamino)-8-oxo-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6R,7R)-7-(2-tert-Butoxycarbonylamino-2-phenyl-acetylamino)-8-oxo-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (6R,7R)-7-(2-tert-Butoxycarbonylamino-2-phenyl-acetylamino)-8-oxo-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

There total 5 articles about (6R,7R)-7-(2-tert-Butoxycarbonylamino-2-phenyl-acetylamino)-8-oxo-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2900-27-8,3601-66-9,14675-97-9,33125-05-2
2-(tert-butoxycarbonylamino)-2-phenylacetic acid

: 1026460-46-7
diphenylmethyl 7β-amino-3-<1-triphenylmethyl-1H-1,2,3-triazol-4-yl>thiomethylthio-3-cephem-4-carboxylate

: 1061680-00-9
(6R,7R)-7-(2-tert-Butoxycarbonylamino-2-phenyl-acetylamino)-8-oxo-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: With 4-methyl-morpholine; P,P-dichlorophenylphosphine oxide; In dichloromethane; at -30 ℃; for 0.5h;
DOI:10.1248/cpb.41.758

Reference yield:

: 76-83-5
trityl chloride

: 1061680-00-9
(6R,7R)-7-(2-tert-Butoxycarbonylamino-2-phenyl-acetylamino)-8-oxo-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) PCl₅, pyridine, 2.) 1,3-butanediol / 1.) CH₂Cl₂, 30 min, 2.) CH₂Cl₂, -30 deg C, 10 min

3: N-methylmorpholine, phenylphosphoryl dichloride / CH₂Cl₂ / 0.5 h / -30 °C

With 4-methyl-morpholine; pyridine; P,P-dichlorophenylphosphine oxide; 1.3-butanediol; phosphorus pentachloride; In dichloromethane;
DOI:10.1248/cpb.41.758

Reference yield:

: 92096-37-2
benzhydryl (6R,7R)-7β-[(phenylacetyl)amino]-3-[(methylsulfonyl)oxy]-3-cephem-4-carboxylate

: 1061680-00-9
(6R,7R)-7-(2-tert-Butoxycarbonylamino-2-phenyl-acetylamino)-8-oxo-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) CH₃ONa / 1.) DMF, MeOH, -60 deg C, 20 min, 2.) DMF, MeOH, -78 deg C, 40 min

2: pyridine / CH₂Cl₂ / 1 h / Ambient temperature

3: 1.) PCl₅, pyridine, 2.) 1,3-butanediol / 1.) CH₂Cl₂, 30 min, 2.) CH₂Cl₂, -30 deg C, 10 min

4: N-methylmorpholine, phenylphosphoryl dichloride / CH₂Cl₂ / 0.5 h / -30 °C

With 4-methyl-morpholine; pyridine; P,P-dichlorophenylphosphine oxide; 1.3-butanediol; phosphorus pentachloride; sodium methylate; In dichloromethane;
DOI:10.1248/cpb.41.758