(3'-nitrobiphenyl-4-yl)[5-(3-nitrophenyl)benzofuran-2-yl]methanone

Base Information

• Chemical Name: (3'-nitrobiphenyl-4-yl)[5-(3-nitrophenyl)benzofuran-2-yl]methanone
• CAS No.: 1370015-99-8
• Molecular Formula: C₂₇H₁₆N₂O₆
• Molecular Weight: 464.434
• Mol file: 1370015-99-8.mol

Synonyms:(3'-nitrobiphenyl-4-yl)[5-(3-nitrophenyl)benzofuran-2-yl]methanone

Chemical Property of (3'-nitrobiphenyl-4-yl)[5-(3-nitrophenyl)benzofuran-2-yl]methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3'-nitrobiphenyl-4-yl)[5-(3-nitrophenyl)benzofuran-2-yl]methanone

There total 3 articles about (3'-nitrobiphenyl-4-yl)[5-(3-nitrophenyl)benzofuran-2-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(5-bromo-1-benzofuran-2-yl)(4-bromophenyl)methanone (83806-46-6) + m-nitrobenzene boronic acid (13331-27-6) → (3'-nitrobiphenyl-4-yl)[5-(3-nitrophenyl)benzofuran-2-yl]methanone (1370015-99-8)

Guidance literature:

(5-bromo-1-benzofuran-2-yl)(4-bromophenyl)methanone; m-nitrobenzene boronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 110 ℃; for 5h; Inert atmosphere;

With dihydrogen peroxide; In ethanol; water; toluene; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1007/s00044-012-0017-y

Reference yield:

para-bromophenacyl bromide (99-73-0,132309-76-3) → (3'-nitrobiphenyl-4-yl)[5-(3-nitrophenyl)benzofuran-2-yl]methanone (1370015-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap; sodium carbonate / water / 5 h / 80 °C

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; ethanol / 5 h / 110 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; 2.1: |Suzuki Coupling;

DOI:10.1007/s00044-012-0017-y

Reference yield:

5-bromosalicyclaldehyde (1761-61-1) → (3'-nitrobiphenyl-4-yl)[5-(3-nitrophenyl)benzofuran-2-yl]methanone (1370015-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap; sodium carbonate / water / 5 h / 80 °C

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; ethanol / 5 h / 110 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; 2.1: |Suzuki Coupling;

DOI:10.1007/s00044-012-0017-y

upstream raw materials:

(5-bromo-1-benzofuran-2-yl)(4-bromophenyl)methanone

m-nitrobenzene boronic acid

para-bromophenacyl bromide

5-bromosalicyclaldehyde

Downstream raw materials:

(3'-nitrobiphenyl-4-yl)[5-(3-nitrophenyl)benzofuran-2-yl]methanol