3-<2-<(trimethylsilyl)methyl-2-propenyl>amino>-2-<2'-(2-(benzyloxy)ethyl)-4',5'-(methylenedioxy)phenyl>-2-cyclopenten-1-one

Base Information

Chemical Name:3-<2-<(trimethylsilyl)methyl-2-propenyl>amino>-2-<2'-(2-(benzyloxy)ethyl)-4',5'-(methylenedioxy)phenyl>-2-cyclopenten-1-one
CAS No.:183114-95-6
Molecular Formula:C₂₈H₃₅NO₄Si
Molecular Weight:477.676
Hs Code.:

Synonyms:3-<2-<(trimethylsilyl)methyl-2-propenyl>amino>-2-<2'-(2-(benzyloxy)ethyl)-4',5'-(methylenedioxy)phenyl>-2-cyclopenten-1-one

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Chemical Property of 3-<2-<(trimethylsilyl)methyl-2-propenyl>amino>-2-<2'-(2-(benzyloxy)ethyl)-4',5'-(methylenedioxy)phenyl>-2-cyclopenten-1-one

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Technology Process of 3-<2-<(trimethylsilyl)methyl-2-propenyl>amino>-2-<2'-(2-(benzyloxy)ethyl)-4',5'-(methylenedioxy)phenyl>-2-cyclopenten-1-one

There total 11 articles about 3-<2-<(trimethylsilyl)methyl-2-propenyl>amino>-2-<2'-(2-(benzyloxy)ethyl)-4',5'-(methylenedioxy)phenyl>-2-cyclopenten-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 126266-15-7
<2-((trimethylsilyl)methyl)-2-propenyl>amine

: 126266-14-6
3-chloro-2-<2'-(2-(benzyloxy)ethyl)-4',5'-(methylenedioxy)phenyl>-2-cyclopenten-1-one

: 183114-95-6
3-<2-<(trimethylsilyl)methyl-2-propenyl>amino>-2-<2'-(2-(benzyloxy)ethyl)-4',5'-(methylenedioxy)phenyl>-2-cyclopenten-1-one

Guidance literature:: With potassium carbonate; In water; acetonitrile; at 75 - 80 ℃; for 67h;
DOI:10.1021/jo961179s

Reference yield:

: 52199-45-8
2-(2'-iodo-4',5'-methylenedioxyphenyl)ethanol

: 183114-95-6
3-<2-<(trimethylsilyl)methyl-2-propenyl>amino>-2-<2'-(2-(benzyloxy)ethyl)-4',5'-(methylenedioxy)phenyl>-2-cyclopenten-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / 86.8percent KOH / dimethylsulfoxide / 4 h / 25 °C

2: 87 percent / n-BuLi / tetrahydrofuran; hexane / 9 h / -78 °C

3: 1.) BF₃*OEt₂, 2.) TFA / 1.) CH₂Cl₂, -78 deg C, 10.5 h, 2.) 0 deg C, sonicated

4: 100 percent / 0.108 M NaOH / H₂O / 2 h / 25 °C

5: 91 percent / ClCOCOCl / benzene / 24 h / 50 - 55 °C

6: 76 percent / K₂CO₃ / acetonitrile; H₂O / 67 h / 75 - 80 °C

With potassium hydroxide; sodium hydroxide; n-butyllithium; oxalyl dichloride; boron trifluoride diethyl etherate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; hexane; water; dimethyl sulfoxide; acetonitrile; benzene;
DOI:10.1021/jo961179s

Reference yield:

: 183114-92-3
2-(2-iodo-4,5-(methylenedioxy)phenyl)ethyl benzyl ether

: 183114-95-6
3-<2-<(trimethylsilyl)methyl-2-propenyl>amino>-2-<2'-(2-(benzyloxy)ethyl)-4',5'-(methylenedioxy)phenyl>-2-cyclopenten-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / n-BuLi / tetrahydrofuran; hexane / 9 h / -78 °C

2: 1.) BF₃*OEt₂, 2.) TFA / 1.) CH₂Cl₂, -78 deg C, 10.5 h, 2.) 0 deg C, sonicated

3: 100 percent / 0.108 M NaOH / H₂O / 2 h / 25 °C

4: 91 percent / ClCOCOCl / benzene / 24 h / 50 - 55 °C

5: 76 percent / K₂CO₃ / acetonitrile; H₂O / 67 h / 75 - 80 °C

With sodium hydroxide; n-butyllithium; oxalyl dichloride; boron trifluoride diethyl etherate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; hexane; water; acetonitrile; benzene;
DOI:10.1021/jo961179s