(R)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-2-ethyl-pentanenitrile

Base Information

• Chemical Name: (R)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-2-ethyl-pentanenitrile
• CAS No.: 195434-03-8
• Molecular Formula: C₁₇H₂₅N₂O₃P
• Molecular Weight: 336.371

Synonyms:(R)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-2-ethyl-pentanenitrile

Chemical Property of (R)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-2-ethyl-pentanenitrile

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-2-ethyl-pentanenitrile

There total 4 articles about (R)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-2-ethyl-pentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(E)-(R)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ5-[1,3,2]oxazaphospholidin-2-yloxy)-2-ethyl-pent-3-enenitrile (195433-98-8) → (R)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ5-[1,3,2]oxazaphospholidin-2-yloxy)-2-ethyl-pentanenitrile (195434-03-8)

Guidance literature:

With acetic acid; N,N-dimethyl-4-(2-pyridylazo)aniline; In 1,4-dioxane; at 50 ℃;

DOI:10.1021/jo970854a

Reference yield:

(E)-2-hydroxypent-3-enenitrile (193805-19-5) → (R)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ5-[1,3,2]oxazaphospholidin-2-yloxy)-2-ethyl-pentanenitrile (195434-03-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 53 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: n-BuLi, DMPU / tetrahydrofuran; hexane / -108 °C / 1.) 20 min, 2.) 4 h

3: 71 percent / PADA, acetic acid / dioxane / 50 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; acetic acid; triethylamine; N,N-dimethyl-4-(2-pyridylazo)aniline; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;

DOI:10.1021/jo970854a

Reference yield:

(4S)-2-chloro-3,4r-dimethyl-5t-phenyl-[1,3,2]oxazaphospholidine 2ξ-oxide (13897-77-3,28080-18-4,28080-19-5,31060-10-3,31060-12-5,53625-09-5,53625-11-9,54750-12-8,54750-13-9,72691-41-9,149116-52-9) → (R)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ5-[1,3,2]oxazaphospholidin-2-yloxy)-2-ethyl-pentanenitrile (195434-03-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 53 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: n-BuLi, DMPU / tetrahydrofuran; hexane / -108 °C / 1.) 20 min, 2.) 4 h

3: 71 percent / PADA, acetic acid / dioxane / 50 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; acetic acid; triethylamine; N,N-dimethyl-4-(2-pyridylazo)aniline; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;

DOI:10.1021/jo970854a

upstream raw materials:

(E)-(R)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-2-ethyl-pent-3-enenitrile

(E)-2-hydroxypent-3-enenitrile

(4S)-2-chloro-3,4r-dimethyl-5t-phenyl-[1,3,2]oxazaphospholidine 2ξ-oxide

(E)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-pent-3-enenitrile

Downstream raw materials:

(R)-2-ethyl-2-hydroxypentanoic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 195434-03-8 (R)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-2-ethyl-pentanenitrile

Send

Send

Metric Ton KG G Pound L ML

Send

Send