2,2-Dimethyl-propionic acid (2R,4S,6R)-2-benzyloxymethyl-6-[(2S,6S)-6-(2-methyl-oxazol-4-yl)-4-triethylsilanyloxy-5,6-dihydro-2H-pyran-2-ylmethyl]-tetrahydro-pyran-4-yl ester

Base Information

• Chemical Name: 2,2-Dimethyl-propionic acid (2R,4S,6R)-2-benzyloxymethyl-6-[(2S,6S)-6-(2-methyl-oxazol-4-yl)-4-triethylsilanyloxy-5,6-dihydro-2H-pyran-2-ylmethyl]-tetrahydro-pyran-4-yl ester
• CAS No.: 570389-20-7
• Molecular Formula: C₃₄H₅₁NO₇Si
• Molecular Weight: 613.867

Synonyms:2,2-Dimethyl-propionic acid (2R,4S,6R)-2-benzyloxymethyl-6-[(2S,6S)-6-(2-methyl-oxazol-4-yl)-4-triethylsilanyloxy-5,6-dihydro-2H-pyran-2-ylmethyl]-tetrahydro-pyran-4-yl ester

Chemical Property of 2,2-Dimethyl-propionic acid (2R,4S,6R)-2-benzyloxymethyl-6-[(2S,6S)-6-(2-methyl-oxazol-4-yl)-4-triethylsilanyloxy-5,6-dihydro-2H-pyran-2-ylmethyl]-tetrahydro-pyran-4-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid (2R,4S,6R)-2-benzyloxymethyl-6-[(2S,6S)-6-(2-methyl-oxazol-4-yl)-4-triethylsilanyloxy-5,6-dihydro-2H-pyran-2-ylmethyl]-tetrahydro-pyran-4-yl ester

There total 10 articles about 2,2-Dimethyl-propionic acid (2R,4S,6R)-2-benzyloxymethyl-6-[(2S,6S)-6-(2-methyl-oxazol-4-yl)-4-triethylsilanyloxy-5,6-dihydro-2H-pyran-2-ylmethyl]-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyloxyacetoaldehyde (60656-87-3) → 2,2-Dimethyl-propionic acid (2R,4S,6R)-2-benzyloxymethyl-6-[(2S,6S)-6-(2-methyl-oxazol-4-yl)-4-triethylsilanyloxy-5,6-dihydro-2H-pyran-2-ylmethyl]-tetrahydro-pyran-4-yl ester (570389-20-7)

Guidance literature:

Multi-step reaction with 10 steps

1.1: 87 percent / PPTS; MeOH / [(R,R)Cu(Ph-pybox)](SbF₆)2 / CH₂Cl₂ / 16 h / -78 °C

2.1: 99 percent / K₂CO₃; MeOH / 17 h / 20 °C

3.1: DIBAL / CH₂Cl₂ / -50 °C

3.2: pyridine; DMAP / CH₂Cl₂ / -78 - 0 °C

4.1: 97 percent / BF₃*OEt₂; TMSOTf; 4 Angstroem mol. sieves / acetonitrile / 1.5 h / -30 - -18 °C

5.1: K₂CO₃; MeOH / 0.5 h / 20 °C

6.1: pyridine; DMAP / CH₂Cl₂ / 16 h / 0 - 20 °C

7.1: OsO₄; NMO / acetone; H₂O

7.2: Pb(OAc)4; Na₂CO₃ / CH₂Cl₂ / 0.5 h / 0 - 20 °C

8.1: LiCl; DBU / acetonitrile; CH₂Cl₂ / 3 h / 20 °C

9.1: Et₃N / diethyl ether / 0 - 20 °C

10.1: Jacobsen catalyst; 4 Angstroem mol. sieves / acetone / 3 h

10.2: 38 h

With pyridine; methanol; dmap; osmium(VIII) oxide; N-methyl-2-indolinone; (S,S)-chloro[2,2'-[1,2-cyclohexanediylbis(nitrilomethylidyne)]bis-[4,6-bis(1,1-dimethylethyl)phenolato]]^(2-)-N,N',O,O'-manganese; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; [(R,R)Cu(Ph-pybox)](SbF₆)2; In diethyl ether; dichloromethane; water; acetone; acetonitrile; 1.1: Evans aldol reaction / 10.1: Jacobsen hetero Diels-Alder reaction;

DOI:10.1016/S0040-4039(03)00754-8

Reference yield:

(R)-(3-benzyloxy-2-hydroxypropyl)-2,2-dimethyl-1,3-dioxin-4-one (570389-08-1) → 2,2-Dimethyl-propionic acid (2R,4S,6R)-2-benzyloxymethyl-6-[(2S,6S)-6-(2-methyl-oxazol-4-yl)-4-triethylsilanyloxy-5,6-dihydro-2H-pyran-2-ylmethyl]-tetrahydro-pyran-4-yl ester (570389-20-7)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 99 percent / K₂CO₃; MeOH / 17 h / 20 °C

2.1: DIBAL / CH₂Cl₂ / -50 °C

2.2: pyridine; DMAP / CH₂Cl₂ / -78 - 0 °C

3.1: 97 percent / BF₃*OEt₂; TMSOTf; 4 Angstroem mol. sieves / acetonitrile / 1.5 h / -30 - -18 °C

4.1: K₂CO₃; MeOH / 0.5 h / 20 °C

5.1: pyridine; DMAP / CH₂Cl₂ / 16 h / 0 - 20 °C

6.1: OsO₄; NMO / acetone; H₂O

6.2: Pb(OAc)4; Na₂CO₃ / CH₂Cl₂ / 0.5 h / 0 - 20 °C

7.1: LiCl; DBU / acetonitrile; CH₂Cl₂ / 3 h / 20 °C

8.1: Et₃N / diethyl ether / 0 - 20 °C

9.1: Jacobsen catalyst; 4 Angstroem mol. sieves / acetone / 3 h

9.2: 38 h

With pyridine; methanol; dmap; osmium(VIII) oxide; N-methyl-2-indolinone; (S,S)-chloro[2,2'-[1,2-cyclohexanediylbis(nitrilomethylidyne)]bis-[4,6-bis(1,1-dimethylethyl)phenolato]]^(2-)-N,N',O,O'-manganese; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; boron trifluoride diethyl etherate; diisobutylaluminium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; In diethyl ether; dichloromethane; water; acetone; acetonitrile; 9.1: Jacobsen hetero Diels-Alder reaction;

DOI:10.1016/S0040-4039(03)00754-8

Reference yield:

(R)-6-Benzyloxymethyl-dihydro-pyran-2,4-dione (570389-10-5) → 2,2-Dimethyl-propionic acid (2R,4S,6R)-2-benzyloxymethyl-6-[(2S,6S)-6-(2-methyl-oxazol-4-yl)-4-triethylsilanyloxy-5,6-dihydro-2H-pyran-2-ylmethyl]-tetrahydro-pyran-4-yl ester (570389-20-7)

Guidance literature:

Multi-step reaction with 8 steps

1.1: DIBAL / CH₂Cl₂ / -50 °C

1.2: pyridine; DMAP / CH₂Cl₂ / -78 - 0 °C

2.1: 97 percent / BF₃*OEt₂; TMSOTf; 4 Angstroem mol. sieves / acetonitrile / 1.5 h / -30 - -18 °C

3.1: K₂CO₃; MeOH / 0.5 h / 20 °C

4.1: pyridine; DMAP / CH₂Cl₂ / 16 h / 0 - 20 °C

5.1: OsO₄; NMO / acetone; H₂O

5.2: Pb(OAc)4; Na₂CO₃ / CH₂Cl₂ / 0.5 h / 0 - 20 °C

6.1: LiCl; DBU / acetonitrile; CH₂Cl₂ / 3 h / 20 °C

7.1: Et₃N / diethyl ether / 0 - 20 °C

8.1: Jacobsen catalyst; 4 Angstroem mol. sieves / acetone / 3 h

8.2: 38 h

With pyridine; methanol; dmap; osmium(VIII) oxide; N-methyl-2-indolinone; (S,S)-chloro[2,2'-[1,2-cyclohexanediylbis(nitrilomethylidyne)]bis-[4,6-bis(1,1-dimethylethyl)phenolato]]^(2-)-N,N',O,O'-manganese; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; boron trifluoride diethyl etherate; diisobutylaluminium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; In diethyl ether; dichloromethane; water; acetone; acetonitrile; 8.1: Jacobsen hetero Diels-Alder reaction;

DOI:10.1016/S0040-4039(03)00754-8

upstream raw materials:

2-methyl-1,3-oxazole-4-carbaldehyde

2,2-Dimethyl-propionic acid (2R,4S,6S)-2-benzyloxymethyl-6-((E)-4-triethylsilanyloxy-penta-2,4-dienyl)-tetrahydro-pyran-4-yl ester

benzyloxyacetoaldehyde

(R)-(3-benzyloxy-2-hydroxypropyl)-2,2-dimethyl-1,3-dioxin-4-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 570389-20-7 2,2-Dimethyl-propionic acid (2R,4S,6R)-2-benzyloxymethyl-6-[(2S,6S)-6-(2-methyl-oxazol-4-yl)-4-triethylsilanyloxy-5,6-dihydro-2H-pyran-2-ylmethyl]-tetrahydro-pyran-4-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send