dimethyl 5-fluoromethylisophthalate

Base Information

• Chemical Name: dimethyl 5-fluoromethylisophthalate
• CAS No.: 1311298-91-5
• Molecular Formula: C₁₁H₁₁FO₄
• Molecular Weight: 226.204
• Mol file: 1311298-91-5.mol

Synonyms:dimethyl 5-fluoromethylisophthalate

Chemical Property of dimethyl 5-fluoromethylisophthalate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of dimethyl 5-fluoromethylisophthalate

There total 2 articles about dimethyl 5-fluoromethylisophthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

dimethyl 5-hydroxymethylbenzene-1,3-dicarboxylate (109862-53-5) → dimethyl 5-fluoromethylisophthalate (1311298-91-5)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

1,3,5-tris-(methoxycarbonyl)benzene (2672-58-4) → dimethyl 5-fluoromethylisophthalate (1311298-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.5 h / Inert atmosphere; Reflux

2: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; diethylamino-sulfur trifluoride; In tetrahydrofuran; dichloromethane;

Reference yield: 80.0%

dimethyl 5-fluoromethylisophthalate (1311298-91-5) → methyl 3-fluoromethyl-5-hydroxymethylbenzoate (1311298-93-7)

Guidance literature:

With methanol; sodium tetrahydroborate; In tetrahydrofuran; for 1h; Inert atmosphere; Reflux;

upstream raw materials:

1,3,5-tris-(methoxycarbonyl)benzene

dimethyl 5-hydroxymethylbenzene-1,3-dicarboxylate

Downstream raw materials:

methyl 3-fluoromethyl-5-hydroxymethylbenzoate

methyl 3-aminomethyl-5-fluoromethylbenzoate

3-azidomethyl-5-fluoromethylbenzylalcohol

Refernces