(3R,4R,5S)-2-[(Z)-1-benzoylamino-1-[1-(t-butyldiphenylsiloxy)methyl-2,2-dimethoxypropyl]-carbamoyl]methylidene-3,4-dibenzyloxy-1-(prop-2-en-1-yloxy)carbonyl-5-(methanesulfonyloxy)methylpyrrolidine

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Chemical Name:(3R,4R,5S)-2-[(Z)-1-benzoylamino-1-[1-(t-butyldiphenylsiloxy)methyl-2,2-dimethoxypropyl]-carbamoyl]methylidene-3,4-dibenzyloxy-1-(prop-2-en-1-yloxy)carbonyl-5-(methanesulfonyloxy)methylpyrrolidine
CAS No.:161275-55-4
Molecular Formula:C₅₅H₆₅N₃O₁₂SSi
Molecular Weight:1020.29
Hs Code.:

(3R,4R,5S)-2-[(Z)-1-benzoylamino-1-[1-(t-butyldiphenylsiloxy)methyl-2,2-dimethoxypropyl]-carbamoyl]methylidene-3,4-dibenzyloxy-1-(prop-2-en-1-yloxy)carbonyl-5-(methanesulfonyloxy)methylpyrrolidine

Synonyms:(3R,4R,5S)-2-[(Z)-1-benzoylamino-1-[1-(t-butyldiphenylsiloxy)methyl-2,2-dimethoxypropyl]-carbamoyl]methylidene-3,4-dibenzyloxy-1-(prop-2-en-1-yloxy)carbonyl-5-(methanesulfonyloxy)methylpyrrolidine

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Chemical Property of (3R,4R,5S)-2-[(Z)-1-benzoylamino-1-[1-(t-butyldiphenylsiloxy)methyl-2,2-dimethoxypropyl]-carbamoyl]methylidene-3,4-dibenzyloxy-1-(prop-2-en-1-yloxy)carbonyl-5-(methanesulfonyloxy)methylpyrrolidine

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Technology Process of (3R,4R,5S)-2-[(Z)-1-benzoylamino-1-[1-(t-butyldiphenylsiloxy)methyl-2,2-dimethoxypropyl]-carbamoyl]methylidene-3,4-dibenzyloxy-1-(prop-2-en-1-yloxy)carbonyl-5-(methanesulfonyloxy)methylpyrrolidine

There total 5 articles about (3R,4R,5S)-2-[(Z)-1-benzoylamino-1-[1-(t-butyldiphenylsiloxy)methyl-2,2-dimethoxypropyl]-carbamoyl]methylidene-3,4-dibenzyloxy-1-(prop-2-en-1-yloxy)carbonyl-5-(methanesulfonyloxy)methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 161150-59-0
(3R)-3-amino-4-(t-butyldiphenylsilyl)oxy-2-butanone dimethyl acetal

: 228120-04-5
(E)-4-[(3R,4R,5S)-1-allyloxycarbonyl-3,4-dibenzyloxy-5-(methanesulfonyloxy)methylpyrrolidin-2-ylidene]-2-phenyl-4H-oxazol-5-one

: 161150-62-5
(3R,4R,5S)-2-[(E)-1-benzoylamino-1-[1-(t-butyldiphenylsiloxy)methyl-2,2-dimethoxypropyl]-carbamoyl]methylidene-3,4-dibenzyloxy-1-(prop-2-en-1-yloxy)carbonyl-5-(methanesulfonyloxy)methylpyrrolidine

: 161275-55-4
(3R,4R,5S)-2-[(Z)-1-benzoylamino-1-[1-(t-butyldiphenylsiloxy)methyl-2,2-dimethoxypropyl]-carbamoyl]methylidene-3,4-dibenzyloxy-1-(prop-2-en-1-yloxy)carbonyl-5-(methanesulfonyloxy)methylpyrrolidine

Guidance literature:: With dmap; In toluene; at 50 ℃; for 2h;
DOI:10.1016/S0040-4020(03)00378-8

Reference yield:

: 161150-56-7
[1-(tert-butyldiphenylsilanyloxymethyl)-2-hydroxypropyl]carbamic acid benzyl ester

: 161275-55-4
(3R,4R,5S)-2-[(Z)-1-benzoylamino-1-[1-(t-butyldiphenylsiloxy)methyl-2,2-dimethoxypropyl]-carbamoyl]methylidene-3,4-dibenzyloxy-1-(prop-2-en-1-yloxy)carbonyl-5-(methanesulfonyloxy)methylpyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / sulfur trioxide pyridin complex; Et₃N / dimethylsulfoxide / 2.5 h / 20 °C

2: 97 percent / p-TsOH*H₂O / methanol / 2.5 h / 20 °C

3: 93 percent / H₂ / 10 percent Pd/C / methanol / 14 h / 20 °C / 760 Torr

4: 15 percent / DMAP / toluene / 2 h / 50 °C

With dmap; hydrogen; sulfur trioxide pyridine complex; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In methanol; dimethyl sulfoxide; toluene;
DOI:10.1016/S0040-4020(03)00378-8

Reference yield:

: 161150-57-8
[1-(tert-butyldiphenylsilanyloxymethyl)-2-oxopropyl]carbamic acid benzyl ester

: 161275-55-4
(3R,4R,5S)-2-[(Z)-1-benzoylamino-1-[1-(t-butyldiphenylsiloxy)methyl-2,2-dimethoxypropyl]-carbamoyl]methylidene-3,4-dibenzyloxy-1-(prop-2-en-1-yloxy)carbonyl-5-(methanesulfonyloxy)methylpyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / p-TsOH*H₂O / methanol / 2.5 h / 20 °C

2: 93 percent / H₂ / 10 percent Pd/C / methanol / 14 h / 20 °C / 760 Torr

3: 15 percent / DMAP / toluene / 2 h / 50 °C

With dmap; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; toluene;
DOI:10.1016/S0040-4020(03)00378-8