ethyl 3-{3-(pyridin-3-ylmethyl)-5-[2-(1-pyrrolidinylsulphonylamino)ethyl]phenyl}propanoate

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Chemical Name:ethyl 3-{3-(pyridin-3-ylmethyl)-5-[2-(1-pyrrolidinylsulphonylamino)ethyl]phenyl}propanoate
CAS No.:145690-99-9
Molecular Formula:C₂₃H₃₁N₃O₄S
Molecular Weight:445.583
Hs Code.:

Synonyms:ethyl 3-{3-(pyridin-3-ylmethyl)-5-[2-(1-pyrrolidinylsulphonylamino)ethyl]phenyl}propanoate

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Chemical Property of ethyl 3-{3-(pyridin-3-ylmethyl)-5-[2-(1-pyrrolidinylsulphonylamino)ethyl]phenyl}propanoate

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Technology Process of ethyl 3-{3-(pyridin-3-ylmethyl)-5-[2-(1-pyrrolidinylsulphonylamino)ethyl]phenyl}propanoate

There total 10 articles about ethyl 3-{3-(pyridin-3-ylmethyl)-5-[2-(1-pyrrolidinylsulphonylamino)ethyl]phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-54-9,121697-66-3,1232169-17-3,68271-95-4
pyridine-3-carbonitrile

: 145690-99-9
ethyl 3-{3-(pyridin-3-ylmethyl)-5-[2-(1-pyrrolidinylsulphonylamino)ethyl]phenyl}propanoate

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) n-BuLi / 1.) ether, hexane, -78 deg C, 30 min, 2.) ether, hexane, from -78 deg C to 0 deg C

2: 1.) N₂H₄*H₂O, ethylene glycol, 2.) KOH / 1.) reflux, 45 min, 2.) reflux, 30 min

3: 83 percent / Pd(OAc)2, tri-o-tolylphosphine, Et₃N / acetonitrile / 1 h / Heating

4: 95 percent / HCO₂NH₄ / 10percent Pd/C / ethanol; tetrahydrofuran / 1 h / 60 °C

5: 43 percent / aq. NaOH / ethanol / 0.75 h / Heating

6: diphenyl phosphorazidate, Et₃N / 18 h / Heating

7: TFA / CH₂Cl₂ / 4 h / Ambient temperature

8: 4-(dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 2.5 h / Ambient temperature

With dmap; palladium diacetate; potassium hydroxide; sodium hydroxide; n-butyllithium; diphenyl phosphoryl azide; ammonium formate; hydrazine hydrate; ethylene glycol; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 626-39-1
1,3,5-trisbromobenzene

: 145690-99-9
ethyl 3-{3-(pyridin-3-ylmethyl)-5-[2-(1-pyrrolidinylsulphonylamino)ethyl]phenyl}propanoate

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) n-BuLi / 1.) ether, hexane, -78 deg C, 30 min, 2.) ether, hexane, from -78 deg C to 0 deg C

2: 1.) N₂H₄*H₂O, ethylene glycol, 2.) KOH / 1.) reflux, 45 min, 2.) reflux, 30 min

3: 83 percent / Pd(OAc)2, tri-o-tolylphosphine, Et₃N / acetonitrile / 1 h / Heating

4: 95 percent / HCO₂NH₄ / 10percent Pd/C / ethanol; tetrahydrofuran / 1 h / 60 °C

5: 43 percent / aq. NaOH / ethanol / 0.75 h / Heating

6: diphenyl phosphorazidate, Et₃N / 18 h / Heating

7: TFA / CH₂Cl₂ / 4 h / Ambient temperature

8: 4-(dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 2.5 h / Ambient temperature

With dmap; palladium diacetate; potassium hydroxide; sodium hydroxide; n-butyllithium; diphenyl phosphoryl azide; ammonium formate; hydrazine hydrate; ethylene glycol; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 145691-54-9
3-(3,5-dibromobenzyl)pyridine

: 145690-99-9
ethyl 3-{3-(pyridin-3-ylmethyl)-5-[2-(1-pyrrolidinylsulphonylamino)ethyl]phenyl}propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / Pd(OAc)2, tri-o-tolylphosphine, Et₃N / acetonitrile / 1 h / Heating

2: 95 percent / HCO₂NH₄ / 10percent Pd/C / ethanol; tetrahydrofuran / 1 h / 60 °C

3: 43 percent / aq. NaOH / ethanol / 0.75 h / Heating

4: diphenyl phosphorazidate, Et₃N / 18 h / Heating

5: TFA / CH₂Cl₂ / 4 h / Ambient temperature

6: 4-(dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 2.5 h / Ambient temperature

With dmap; palladium diacetate; sodium hydroxide; diphenyl phosphoryl azide; ammonium formate; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;