Technology Process of 6-benzyloxymethyl-2,6-dimethyl-3-ethoxy-2-cyclohexenone
There total 2 articles about 6-benzyloxymethyl-2,6-dimethyl-3-ethoxy-2-cyclohexenone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium diisopropyl amide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
at -78 - 20 ℃;
DOI:10.1246/bcsj.59.2029
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 91 percent / 1.) LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 - 20 °C
2: 88 percent / 1.) LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 - 20 °C
With
lithium diisopropyl amide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1246/bcsj.59.2029
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) BuLi; 2.) LiBr; 3.) KF / 1.) -78 deg C, THF, hexane, 30 min; 2.) 1 h, -78 deg C, then 1 h, 0 deg C; 3.) ethanol, r.t., 3 h
2: 94 percent / (CH3O)3CH, p-TsOH / diethyl ether / 48 h / Ambient temperature
3: 1.) HB(Sia)2; 2.) Pd(PPh3)4, NaOEt / 1.) THF, 16 h, r.t.; 2.) benzene, ethanol, 6 h reflux
4: 92 percent / aq. HCl / tetrahydrofuran / 6 h / Ambient temperature
With
hydrogenchloride; potassium fluoride; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; HB(Sia)2; sodium ethanolate; toluene-4-sulfonic acid; lithium bromide; trimethyl orthoformate;
In
tetrahydrofuran; diethyl ether;
DOI:10.1246/bcsj.59.2029
