7-fluoro-5-{1-[3-(4-tributylstannylphenyl)propyl]piperidin-4-yl}methyloxybenzo[h]-1,6-naphthyridine

Base Information

Chemical Name:7-fluoro-5-{1-[3-(4-tributylstannylphenyl)propyl]piperidin-4-yl}methyloxybenzo[h]-1,6-naphthyridine
CAS No.:1410703-48-8
Molecular Formula:C₃₉H₅₄FN₃OSn
Molecular Weight:718.586
Hs Code.:

Synonyms:7-fluoro-5-{1-[3-(4-tributylstannylphenyl)propyl]piperidin-4-yl}methyloxybenzo[h]-1,6-naphthyridine

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Chemical Property of 7-fluoro-5-{1-[3-(4-tributylstannylphenyl)propyl]piperidin-4-yl}methyloxybenzo[h]-1,6-naphthyridine

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Technology Process of 7-fluoro-5-{1-[3-(4-tributylstannylphenyl)propyl]piperidin-4-yl}methyloxybenzo[h]-1,6-naphthyridine

There total 7 articles about 7-fluoro-5-{1-[3-(4-tributylstannylphenyl)propyl]piperidin-4-yl}methyloxybenzo[h]-1,6-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1410703-43-3
C₂₇H₂₇FIN₃O

: 813-19-4
bis(tri-n-butyltin)

: 1410703-48-8
7-fluoro-5-{1-[3-(4-tributylstannylphenyl)propyl]piperidin-4-yl}methyloxybenzo[h]-1,6-naphthyridine

Guidance literature:: With palladium diacetate; triphenylphosphine; In water; toluene; at 90 ℃; for 16h; Schlenk technique; Inert atmosphere;
DOI:10.1021/jm300943r

Reference yield:

: 1643-29-4
3-(4-iodophenyl)propionic acid

: 1410703-48-8
7-fluoro-5-{1-[3-(4-tributylstannylphenyl)propyl]piperidin-4-yl}methyloxybenzo[h]-1,6-naphthyridine

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 24 h / 20 °C

2: diisobutylaluminium hydride / tetrahydrofuran; hexane / 15 h / 20 °C / Cooling

3: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

4: palladium diacetate; triphenylphosphine / water; toluene / 16 h / 90 °C / Schlenk technique; Inert atmosphere

With palladium diacetate; sodium hydride; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm300943r

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 1410703-48-8
7-fluoro-5-{1-[3-(4-tributylstannylphenyl)propyl]piperidin-4-yl}methyloxybenzo[h]-1,6-naphthyridine

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 24 h / 20 °C

2: diisobutylaluminium hydride / tetrahydrofuran; hexane / 15 h / 20 °C / Cooling

3: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

4: palladium diacetate; triphenylphosphine / water; toluene / 16 h / 90 °C / Schlenk technique; Inert atmosphere

With palladium diacetate; sodium hydride; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm300943r