5-1,3-[benzodioxol-5-yl]-3',4',5',6'-tetrahydro-2'H-2,4'-bipyridinyl-1'-carboxylic acid tert-butyl ester dihydrochloride

Base Information

Chemical Name:5-1,3-[benzodioxol-5-yl]-3',4',5',6'-tetrahydro-2'H-2,4'-bipyridinyl-1'-carboxylic acid tert-butyl ester dihydrochloride
CAS No.:1093217-90-3
Molecular Formula:C₂₃H₃₀N₂O₄S
Molecular Weight:430.568
Hs Code.:

Synonyms:5-1,3-[benzodioxol-5-yl]-3',4',5',6'-tetrahydro-2'H-2,4'-bipyridinyl-1'-carboxylic acid tert-butyl ester dihydrochloride

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Chemical Property of 5-1,3-[benzodioxol-5-yl]-3',4',5',6'-tetrahydro-2'H-2,4'-bipyridinyl-1'-carboxylic acid tert-butyl ester dihydrochloride

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Technology Process of 5-1,3-[benzodioxol-5-yl]-3',4',5',6'-tetrahydro-2'H-2,4'-bipyridinyl-1'-carboxylic acid tert-butyl ester dihydrochloride

There total 3 articles about 5-1,3-[benzodioxol-5-yl]-3',4',5',6'-tetrahydro-2'H-2,4'-bipyridinyl-1'-carboxylic acid tert-butyl ester dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 622387-27-3
tert-butyl 4-(5-bromopyridin-2-yl)piperidine-1-carboxylate

: 352530-24-6
4-(ethylsulfonyl)phenylboronic acid

: 1093217-90-3
5-1,3-[benzodioxol-5-yl]-3',4',5',6'-tetrahydro-2'H-2,4'-bipyridinyl-1'-carboxylic acid tert-butyl ester dihydrochloride

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile; at 85 ℃; for 0.416667h; microwave;

Reference yield:

: 807618-13-9
(1-(tert-butoxycarbonyl)piperidine-4-yl)zinc(II) iodide

: 1093217-90-3
5-1,3-[benzodioxol-5-yl]-3',4',5',6'-tetrahydro-2'H-2,4'-bipyridinyl-1'-carboxylic acid tert-butyl ester dihydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide / 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; acetonitrile / 0.42 h / 85 °C / microwave

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In 1,2-dimethoxyethane; water; acetonitrile;

Reference yield:

: 301673-14-3
tert-butyl 4-iodopiperidine-1-carboxylate

: 1093217-90-3
5-1,3-[benzodioxol-5-yl]-3',4',5',6'-tetrahydro-2'H-2,4'-bipyridinyl-1'-carboxylic acid tert-butyl ester dihydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: chloro-trimethyl-silane; zinc; 1,1-dibromomethane / 1,2-dimethoxyethane / 58 - 60 °C / Inert atmosphere

2: copper(l) iodide / 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

3: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; acetonitrile / 0.42 h / 85 °C / microwave

With chloro-trimethyl-silane; sodium carbonate; zinc; 1,1-dibromomethane; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In 1,2-dimethoxyethane; water; acetonitrile;