(2S,4S)-2-(2-Piperazin-1-yl-ethylcarbamoyl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Base Information

Chemical Name:(2S,4S)-2-(2-Piperazin-1-yl-ethylcarbamoyl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester
CAS No.:639457-28-6
Molecular Formula:C₃₄H₄₀N₄O₃S
Molecular Weight:584.783
Hs Code.:

Synonyms:(2S,4S)-2-(2-Piperazin-1-yl-ethylcarbamoyl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

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Chemical Property of (2S,4S)-2-(2-Piperazin-1-yl-ethylcarbamoyl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S,4S)-2-(2-Piperazin-1-yl-ethylcarbamoyl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

There total 4 articles about (2S,4S)-2-(2-Piperazin-1-yl-ethylcarbamoyl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.4%

: 110-85-0
piperazine

: 639457-02-6
(2S,4S)-2-[(2-mesyloxyethyl)carbamoyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

: 639457-28-6
(2S,4S)-2-(2-Piperazin-1-yl-ethylcarbamoyl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Guidance literature:: In acetonitrile; at 20 ℃; for 20h;
DOI:10.1016/S0223-5234(03)00143-0

Reference yield:

: 625388-36-5
(2S,4S)-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine-2-carboxylic acid methyl ester

: 639457-28-6
(2S,4S)-2-(2-Piperazin-1-yl-ethylcarbamoyl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 83.2 percent / NaOH / methanol / 5 h / 20 °C

2.1: triethylamine; ethyl chloroformate / CH₂Cl₂ / 0.5 h / 0 °C

2.2: 89.5 percent / CH₂Cl₂ / 1 h / 0 °C

3.1: 91.7 percent / triethylamine / CH₂Cl₂ / 1 h / 0 °C

4.1: 72.4 percent / acetonitrile / 20 h / 20 °C

With sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0223-5234(03)00143-0

Reference yield:

: 639457-00-4
(2S,4S)-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine-2-carboxylic acid

: 639457-28-6
(2S,4S)-2-(2-Piperazin-1-yl-ethylcarbamoyl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; ethyl chloroformate / CH₂Cl₂ / 0.5 h / 0 °C

1.2: 89.5 percent / CH₂Cl₂ / 1 h / 0 °C

2.1: 91.7 percent / triethylamine / CH₂Cl₂ / 1 h / 0 °C

3.1: 72.4 percent / acetonitrile / 20 h / 20 °C

With chloroformic acid ethyl ester; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/S0223-5234(03)00143-0