(2R,4E)-2[(5-chloro-2-iodophenyl)amino]-4-(2-oxo-1-phenylpyrrolidin-3-ylidene)butanoic acid ethyl ester

Base Information

Chemical Name:(2R,4E)-2[(5-chloro-2-iodophenyl)amino]-4-(2-oxo-1-phenylpyrrolidin-3-ylidene)butanoic acid ethyl ester
CAS No.:854054-21-0
Molecular Formula:C₂₂H₂₂ClIN₂O₃
Molecular Weight:524.786
Hs Code.:

Synonyms:(2R,4E)-2[(5-chloro-2-iodophenyl)amino]-4-(2-oxo-1-phenylpyrrolidin-3-ylidene)butanoic acid ethyl ester

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Chemical Property of (2R,4E)-2[(5-chloro-2-iodophenyl)amino]-4-(2-oxo-1-phenylpyrrolidin-3-ylidene)butanoic acid ethyl ester

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Technology Process of (2R,4E)-2[(5-chloro-2-iodophenyl)amino]-4-(2-oxo-1-phenylpyrrolidin-3-ylidene)butanoic acid ethyl ester

There total 2 articles about (2R,4E)-2[(5-chloro-2-iodophenyl)amino]-4-(2-oxo-1-phenylpyrrolidin-3-ylidene)butanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 252349-31-8
(4E)-2[(5-chloro-2-iodophenyl)amino]-4-(2-oxo-1-phenylpyrrolidin-3-ylidene)butanoic acid ethyl ester

: 854054-21-0
(2R,4E)-2[(5-chloro-2-iodophenyl)amino]-4-(2-oxo-1-phenylpyrrolidin-3-ylidene)butanoic acid ethyl ester

: C₂₀H₁₇ClIN₂O₃^(1-)*Na⁽¹⁺⁾

Guidance literature:: (4E)-2[(5-chloro-2-iodophenyl)amino]-4-(2-oxo-1-phenylpyrrolidin-3-ylidene)butanoic acid ethyl ester; With ammonia; In water; tert-butyl alcohol; at 39 - 41 ℃; for 19h; pH=6.1 - 6.3; Large scale reaction; Enzymatic reaction;

With sodium hydrogencarbonate; In water; tert-butyl alcohol; at 40 ℃; for 1h; enantioselective reaction; Large scale reaction;
DOI:10.1021/op9001824

Reference yield:

: 252349-31-8
(4E)-2[(5-chloro-2-iodophenyl)amino]-4-(2-oxo-1-phenylpyrrolidin-3-ylidene)butanoic acid ethyl ester

: 854054-21-0
(2R,4E)-2[(5-chloro-2-iodophenyl)amino]-4-(2-oxo-1-phenylpyrrolidin-3-ylidene)butanoic acid ethyl ester

Guidance literature:: In water; tert-butyl alcohol; at 40 - 41 ℃; for 15h; lipozyme RM IM supported enzyme

Reference yield: 74.0%

: 854054-21-0
(2R,4E)-2[(5-chloro-2-iodophenyl)amino]-4-(2-oxo-1-phenylpyrrolidin-3-ylidene)butanoic acid ethyl ester

: 854054-23-2
(2R,4E)-7-chloro-4-(2-oxo-1-phenylpyrrolidin-3-ylidene)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester

Guidance literature:: With triethylamine; triphenylphosphine; palladium dichloride; In toluene; for 3.75h; Reflux; Large scale reaction;
DOI:10.1021/op9001824