4,5,6,7-Tetrahydro-4-(4-phenoxybut-1-yl)-4-benzothiophencarbonic acid methyl ester

Base Information

• Chemical Name: 4,5,6,7-Tetrahydro-4-(4-phenoxybut-1-yl)-4-benzothiophencarbonic acid methyl ester
• CAS No.: 135024-37-2
• Molecular Formula: C₂₀H₂₄O₃S
• Molecular Weight: 344.475

Synonyms:4,5,6,7-Tetrahydro-4-(4-phenoxybut-1-yl)-4-benzothiophencarbonic acid methyl ester

Chemical Property of 4,5,6,7-Tetrahydro-4-(4-phenoxybut-1-yl)-4-benzothiophencarbonic acid methyl ester

Chemical Property:

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Technology Process of 4,5,6,7-Tetrahydro-4-(4-phenoxybut-1-yl)-4-benzothiophencarbonic acid methyl ester

There total 4 articles about 4,5,6,7-Tetrahydro-4-(4-phenoxybut-1-yl)-4-benzothiophencarbonic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-keto-4,5,6,7-tetrahydrothianaphthene (13414-95-4) → 4,5,6,7-Tetrahydro-4-(4-phenoxybut-1-yl)-4-benzothiophencarbonic acid methyl ester (135024-37-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) t-BuOK / 1) DME, t-BuOH, 1,5 h, 2) DME, r.t., overnight

2: 75 percent / HCl gas / CHCl₃ / 4 h / Ambient temperature

3: 92 percent / H₂O / 1) r.t., overnight, 2) 40 deg C, 1,5 h

4: 1) diisopropylamine, BuLi / 1) THF, hexane, ether, -80 deg C, 1,5 h, 2) -80 deg C -> r.t.

With hydrogenchloride; n-butyllithium; potassium tert-butylate; water; diisopropylamine; In chloroform;

Reference yield:

4,5,6,7-Tetrahydro-4-benzothiophencarbonitrile (134982-97-1) → 4,5,6,7-Tetrahydro-4-(4-phenoxybut-1-yl)-4-benzothiophencarbonic acid methyl ester (135024-37-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / HCl gas / CHCl₃ / 4 h / Ambient temperature

2: 92 percent / H₂O / 1) r.t., overnight, 2) 40 deg C, 1,5 h

3: 1) diisopropylamine, BuLi / 1) THF, hexane, ether, -80 deg C, 1,5 h, 2) -80 deg C -> r.t.

With hydrogenchloride; n-butyllithium; water; diisopropylamine; In chloroform;

Reference yield:

4,5,6,7-Tetrahydrobenzothiophen-4-imidocarboxylic acid methylester hydrochloride (134982-98-2) → 4,5,6,7-Tetrahydro-4-(4-phenoxybut-1-yl)-4-benzothiophencarbonic acid methyl ester (135024-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / H₂O / 1) r.t., overnight, 2) 40 deg C, 1,5 h

2: 1) diisopropylamine, BuLi / 1) THF, hexane, ether, -80 deg C, 1,5 h, 2) -80 deg C -> r.t.

With n-butyllithium; water; diisopropylamine;

upstream raw materials:

4-bromophenyl butyl ether

4,5,6,7-Tetrahydro-4-benzothiophen carboxylic acid methylester

4-keto-4,5,6,7-tetrahydrothianaphthene

4,5,6,7-Tetrahydro-4-benzothiophencarbonitrile

Downstream raw materials:

4,5,6,7-Tetrahydro-4-(4-phenoxybut-1-yl)-4-benzothiophencarbonic acid

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