2-(8-(4-(dimethylamino)phenyl)-2-methyl-7-oxo-3,7-dihydropyrano[3,2-e]indol-1-yl)butanoic acid

Base Information

Chemical Name:2-(8-(4-(dimethylamino)phenyl)-2-methyl-7-oxo-3,7-dihydropyrano[3,2-e]indol-1-yl)butanoic acid
CAS No.:1291090-47-5
Molecular Formula:C₂₄H₂₄N₂O₄
Molecular Weight:404.466
Hs Code.:

Synonyms:2-(8-(4-(dimethylamino)phenyl)-2-methyl-7-oxo-3,7-dihydropyrano[3,2-e]indol-1-yl)butanoic acid

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Chemical Property of 2-(8-(4-(dimethylamino)phenyl)-2-methyl-7-oxo-3,7-dihydropyrano[3,2-e]indol-1-yl)butanoic acid

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Technology Process of 2-(8-(4-(dimethylamino)phenyl)-2-methyl-7-oxo-3,7-dihydropyrano[3,2-e]indol-1-yl)butanoic acid

There total 4 articles about 2-(8-(4-(dimethylamino)phenyl)-2-methyl-7-oxo-3,7-dihydropyrano[3,2-e]indol-1-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1291090-44-2
methyl 2-(8-bromo-2-methyl-7-oxo-3,7-dihydropyrano[3,2-e]indol-1-yl)butanoate

: 28611-39-4
4-(dimethylamino)benzene-boronic acid

: 1291090-47-5
2-(8-(4-(dimethylamino)phenyl)-2-methyl-7-oxo-3,7-dihydropyrano[3,2-e]indol-1-yl)butanoic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; In ethanol; toluene; at 90 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.tet.2011.01.075

Reference yield:

: 3128-07-2
6-oxoheptanoic acid

: 1291090-47-5
2-(8-(4-(dimethylamino)phenyl)-2-methyl-7-oxo-3,7-dihydropyrano[3,2-e]indol-1-yl)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / -5 °C

1.2: 5 h / -5 °C

1.3: 4 h / 80 °C

2.1: thionyl chloride / 1.5 h / Reflux

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate / ethanol; toluene / 6 h / 90 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; water; potassium carbonate; sodium nitrite; In ethanol; water; toluene; 1.3: Fischer indole synthesis / 3.1: Suzuki coupling;
DOI:10.1016/j.tet.2011.01.075

Reference yield:

: 405916-09-8
6-amino-3-bromo-2H-chromen-2-one

: 1291090-47-5
2-(8-(4-(dimethylamino)phenyl)-2-methyl-7-oxo-3,7-dihydropyrano[3,2-e]indol-1-yl)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / -5 °C

1.2: 5 h / -5 °C

1.3: 4 h / 80 °C

2.1: thionyl chloride / 1.5 h / Reflux

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate / ethanol; toluene / 6 h / 90 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; water; potassium carbonate; sodium nitrite; In ethanol; water; toluene; 1.3: Fischer indole synthesis / 3.1: Suzuki coupling;
DOI:10.1016/j.tet.2011.01.075