[(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isobutyl-tetrahydro-thiophen-3-yl ester

Base Information

Chemical Name:[(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isobutyl-tetrahydro-thiophen-3-yl ester
CAS No.:1053608-64-2
Molecular Formula:C₃₃H₅₃N₃O₄S
Molecular Weight:587.868
Hs Code.:

[(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isobutyl-tetrahydro-thiophen-3-yl ester

Synonyms:[(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isobutyl-tetrahydro-thiophen-3-yl ester

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Chemical Property of [(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isobutyl-tetrahydro-thiophen-3-yl ester

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Technology Process of [(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isobutyl-tetrahydro-thiophen-3-yl ester

There total 10 articles about [(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isobutyl-tetrahydro-thiophen-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136465-89-9
(2S)-2-[1'(S)-1-azido-2-phenylethyl]oxirane

: 1053608-64-2
[(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isobutyl-tetrahydro-thiophen-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / propan-2-ol / 80 °C

2: H₂, AcOH / 10percent Pd/C / methanol; tetrahydrofuran

3: CH₂Cl₂ / 12 h / 24 °C

With hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm00034a016

Reference yield:

: 128019-40-9,149510-73-6,136465-81-1,168899-60-3
(3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide

: 1053608-64-2
[(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isobutyl-tetrahydro-thiophen-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / propan-2-ol / 80 °C

2: H₂, AcOH / 10percent Pd/C / methanol; tetrahydrofuran

3: CH₂Cl₂ / 12 h / 24 °C

With hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm00034a016

Reference yield:

: 136465-90-2
N-tert-butyl-2-<2(R)-hydroxy-4-phenyl-3(S)-azidobutyl>decahydro(4aS,8aS)-isoquinoline-3(S)-carboxamide

: 1053608-64-2
[(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isobutyl-tetrahydro-thiophen-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂, AcOH / 10percent Pd/C / methanol; tetrahydrofuran

2: CH₂Cl₂ / 12 h / 24 °C

With hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00034a016