Technology Process of N-(2,3-dimethoxybenzoyl)-8,9-methylenedioxy-6-oxo-1,2,3,4,5,6-hexahydro-3-benzazocine
There total 11 articles about N-(2,3-dimethoxybenzoyl)-8,9-methylenedioxy-6-oxo-1,2,3,4,5,6-hexahydro-3-benzazocine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 99 percent / H2, AcOH / 10percent Pd/C / methanol / 3 h / 2942.03 Torr
2: 93 percent / LiAlH4 / tetrahydrofuran / 0.17 h / Ambient temperature
3: 100 percent / SOCl2 / CH2Cl2 / 2 h / Heating
4: 72 percent / 28percent NaOMe in MeOH / 1.5 h / Heating
5: 1.) 35percent H2O2, 2.) PtO2 / 1.) CHCl3, MeOH, RT, 15 h, 2.) CHCl3, MeOH, 4.5 h
6: tetrahydrofuran / 1 h / Heating
7: 100 percent / H2 / 10percent Pd/C / methanol / 15 h / 760 Torr
8: 79 percent / 10percent aq. NaOH / 1,2-dimethoxy-ethane / 0.17 h
9: 92 percent / 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one / CH2Cl2 / 0.5 h / Ambient temperature
With
platinum(IV) oxide; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; hydrogen; dihydrogen peroxide; sodium methylate; Dess-Martin periodane; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1016/0040-4020(96)00900-3
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 72 percent / 28percent NaOMe in MeOH / 1.5 h / Heating
2: 1.) 35percent H2O2, 2.) PtO2 / 1.) CHCl3, MeOH, RT, 15 h, 2.) CHCl3, MeOH, 4.5 h
3: tetrahydrofuran / 1 h / Heating
4: 100 percent / H2 / 10percent Pd/C / methanol / 15 h / 760 Torr
5: 79 percent / 10percent aq. NaOH / 1,2-dimethoxy-ethane / 0.17 h
6: 92 percent / 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one / CH2Cl2 / 0.5 h / Ambient temperature
With
platinum(IV) oxide; sodium hydroxide; hydrogen; dihydrogen peroxide; sodium methylate; Dess-Martin periodane;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1016/0040-4020(96)00900-3
