N-(2-chlorophenyl)piperidin-4-amine

Base Information

• Chemical Name: N-(2-chlorophenyl)piperidin-4-amine
• CAS No.: 886507-08-0
• Molecular Formula: C₁₁H₁₅ClN₂
• Molecular Weight: 210.706
• European Community (EC) Number: 822-204-6

Synonyms:N-(2-chlorophenyl)piperidin-4-amine;886507-08-0;(2-Chloro-phenyl)-piperidin-4-yl-amine;SCHEMBL83169;MFCD06740675;AKOS003594732;CS-0252925;FT-0766326;EN300-62029;Z728910438

Chemical Property of N-(2-chlorophenyl)piperidin-4-amine

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 210.0923762
• Heavy Atom Count: 14
• Complexity: 169

Purity/Quality:

98% ^*data from raw suppliers

N-(2-Chlorophenyl)piperidin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CNCCC1NC2=CC=CC=C2Cl

Technology Process of N-(2-chlorophenyl)piperidin-4-amine

There total 3 articles about N-(2-chlorophenyl)piperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-chloro-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester (946399-73-1) → C11H15ClN2 (886507-08-0)

Guidance literature:

With trifluoroacetic acid; In 1,2-dimethoxyethane; at 20 ℃; for 3h;

Reference yield:

o-chloroaniline (95-51-2) → C11H15ClN2 (886507-08-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / methanol / 20 °C

1.2: 1 h / 20 °C / Cooling with ice

2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With acetic acid; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1016/j.bioorg.2021.105354

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → C11H15ClN2 (886507-08-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / methanol / 20 °C

1.2: 1 h / 20 °C / Cooling with ice

2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With acetic acid; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1016/j.bioorg.2021.105354

upstream raw materials:

4-(2-chloro-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester

o-chloroaniline

N-tert-butyloxycarbonylpiperidin-4-one

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