3-((2-(6-methoxy-1H-indol-3-yl)ethyl)amino)-3-(2-nitrophenyl)pyrrolidin-2-one

Base Information

Chemical Name:3-((2-(6-methoxy-1H-indol-3-yl)ethyl)amino)-3-(2-nitrophenyl)pyrrolidin-2-one
CAS No.:1360548-51-1
Molecular Formula:C₂₁H₂₂N₄O₄
Molecular Weight:394.43
Hs Code.:

Synonyms:3-((2-(6-methoxy-1H-indol-3-yl)ethyl)amino)-3-(2-nitrophenyl)pyrrolidin-2-one

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Chemical Property of 3-((2-(6-methoxy-1H-indol-3-yl)ethyl)amino)-3-(2-nitrophenyl)pyrrolidin-2-one

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Technology Process of 3-((2-(6-methoxy-1H-indol-3-yl)ethyl)amino)-3-(2-nitrophenyl)pyrrolidin-2-one

There total 8 articles about 3-((2-(6-methoxy-1H-indol-3-yl)ethyl)amino)-3-(2-nitrophenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41340-31-2
2-(6-methoxy-1H-indol-3-yl)ethan-1-ol

: 1360548-51-1
3-((2-(6-methoxy-1H-indol-3-yl)ethyl)amino)-3-(2-nitrophenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 5.5 h / 20 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: water; triphenylphosphine / tetrahydrofuran / 8 h / 60 °C / Inert atmosphere

4: calcium chloride / tetrahydrofuran; methanol / 60 h / 80 °C / Inert atmosphere

With water; sodium tris(acetoxy)borohydride; triphenylphosphine; calcium chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; 3: Staudinger reaction;
DOI:10.1021/ol300249y

Reference yield:

: C₂₃H₂₈N₄O₅

: 1360548-51-1
3-((2-(6-methoxy-1H-indol-3-yl)ethyl)amino)-3-(2-nitrophenyl)pyrrolidin-2-one

Guidance literature:: With calcium chloride; In tetrahydrofuran; methanol; at 80 ℃; for 60h; Inert atmosphere;
DOI:10.1021/ol300249y

Reference yield:

: 1360548-50-0
ethyl 4-azido-2-((2-(6-methoxy-1H-indol-3-yl)ethyl)amino)-2-(2-nitrophenyl)butanoate

: 1360548-51-1
3-((2-(6-methoxy-1H-indol-3-yl)ethyl)amino)-3-(2-nitrophenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: water; triphenylphosphine / tetrahydrofuran / 8 h / 60 °C / Inert atmosphere

2: calcium chloride / tetrahydrofuran; methanol / 60 h / 80 °C / Inert atmosphere

With water; triphenylphosphine; calcium chloride; In tetrahydrofuran; methanol; 1: Staudinger reaction;
DOI:10.1021/ol300249y