C₁₇H₂₀F₃NO₃

Base Information

• Chemical Name: C₁₇H₂₀F₃NO₃
• CAS No.: 1008509-08-7
• Molecular Formula: C₁₇H₂₀F₃NO₃
• Molecular Weight: 343.346
• Mol file: 1008509-08-7.mol

Synonyms:C₁₇H₂₀F₃NO₃

Chemical Property of C₁₇H₂₀F₃NO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₂₀F₃NO₃

There total 5 articles about C₁₇H₂₀F₃NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H22F3NO5 (1000894-33-6) → C17H20F3NO3 (1008509-08-7)

Guidance literature:

With trimethylsilyl iodide; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

C10H15NO3 (1000894-29-0) → C17H20F3NO3 (1008509-08-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

1.2: 0.33 h / 20 °C

1.3: Bargellini Reaction / 0 - 45 °C

2.1: diazomethyl-trimethyl-silane / acetonitrile; methanol / 0 - 20 °C

3.1: ChiralPak AD-5cm 20μm / hexane; isopropyl alcohol / 25 °C / Resolution of racemate

4.1: trimethylsilyl iodide / dichloromethane / 2 h / 20 °C

With trimethylsilyl iodide; sodium hydroxide; diazomethyl-trimethyl-silane; In tetrahydrofuran; methanol; hexane; dichloromethane; isopropyl alcohol; acetonitrile; 1.1: |Bargellini Reaction / 1.2: |Bargellini Reaction;

DOI:10.1021/ml500019s

Reference yield:

1-benzyl-3-piperidone (40114-49-6) → C17H20F3NO3 (1008509-08-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: triethylamine / chloroform / 1 h / 0 - 20 °C

2.1: pyrrolidine / benzene / 20 °C / Inert atmosphere; Dean-Stark; Reflux

2.2: 70 °C / Inert atmosphere; Dean-Stark

3.1: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

3.2: 0.33 h / 20 °C

3.3: Bargellini Reaction / 0 - 45 °C

4.1: diazomethyl-trimethyl-silane / acetonitrile; methanol / 0 - 20 °C

5.1: ChiralPak AD-5cm 20μm / hexane; isopropyl alcohol / 25 °C / Resolution of racemate

6.1: trimethylsilyl iodide / dichloromethane / 2 h / 20 °C

With pyrrolidine; trimethylsilyl iodide; triethylamine; sodium hydroxide; diazomethyl-trimethyl-silane; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; isopropyl alcohol; acetonitrile; benzene; 3.1: |Bargellini Reaction / 3.2: |Bargellini Reaction;

DOI:10.1021/ml500019s

upstream raw materials:

C₁₉H₂₂F₃NO₅

1-benzyl-3-piperidone

C₁₀H₁₅NO₃

C₁₈H₂₀F₃NO₅

Downstream raw materials:

C₂₄H₂₂F₆N₂O₄

C₃₆H₄₀F₆N₄O₅

C₃₅H₃₈F₆N₄O₆

C₂₃H₂₀F₆N₂O₄