6-(2,4-dimethylfuran-3-yl)-7-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-5-carbonitrile

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Chemical Name:6-(2,4-dimethylfuran-3-yl)-7-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-5-carbonitrile
CAS No.:1402652-65-6
Molecular Formula:C₂₀H₁₈N₂O₂
Molecular Weight:318.375
Hs Code.:

Synonyms:6-(2,4-dimethylfuran-3-yl)-7-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-5-carbonitrile

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Chemical Property of 6-(2,4-dimethylfuran-3-yl)-7-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-5-carbonitrile

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Technology Process of 6-(2,4-dimethylfuran-3-yl)-7-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-5-carbonitrile

There total 11 articles about 6-(2,4-dimethylfuran-3-yl)-7-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402652-64-5
4-(5-cyano-7-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizin-6-yl)-3,5-dimethylfuran-2-carboxylic acid

: 1402652-65-6
6-(2,4-dimethylfuran-3-yl)-7-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-5-carbonitrile

Guidance literature:: With copper(I) oxide; In 1-methyl-pyrrolidin-2-one; at 190 ℃; for 0.25h; Inert atmosphere; Sealed vial;

Reference yield:

: 4513-94-4
1H-pyrrole-2-carbonitrile

: 1402652-65-6
6-(2,4-dimethylfuran-3-yl)-7-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-5-carbonitrile

Guidance literature:: Multi-step reaction with 11 steps

1.1: bromine; acetic acid / 23.5 h

2.1: potassium carbonate / acetonitrile / 0.5 h / 80 °C / Inert atmosphere

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave

4.1: 1,2-dimethoxyethane; water / 0.5 h / 120 °C

5.1: Hoveyda-Grubbs catalyst / dichloromethane / 48 h / 20 °C

6.1: hydrogen / 5% rhodium-on-charcoal / ethyl acetate / 5 h / 1875.19 Torr

7.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / Inert atmosphere

8.1: boron tribromide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

8.2: 0 °C

9.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / 100 °C / Inert atmosphere

10.1: water; lithium hydroxide / tetrahydrofuran; methanol / 24 h / 20 °C

11.1: copper(I) oxide / 1-methyl-pyrrolidin-2-one / 0.25 h / 190 °C / Inert atmosphere; Sealed vial

With copper(I) oxide; N-Bromosuccinimide; water; hydrogen; bromine; boron tribromide; potassium carbonate; acetic acid; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5% rhodium-on-charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 34649-19-9
4,5-dibromo-1H-pyrrole-2-carbonitrile

: 1402652-65-6
6-(2,4-dimethylfuran-3-yl)-7-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrolizine-5-carbonitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / acetonitrile / 0.5 h / 80 °C / Inert atmosphere

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave

3.1: 1,2-dimethoxyethane; water / 0.5 h / 120 °C

4.1: Hoveyda-Grubbs catalyst / dichloromethane / 48 h / 20 °C

5.1: hydrogen / 5% rhodium-on-charcoal / ethyl acetate / 5 h / 1875.19 Torr

6.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / Inert atmosphere

7.1: boron tribromide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

7.2: 0 °C

8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / 100 °C / Inert atmosphere

9.1: water; lithium hydroxide / tetrahydrofuran; methanol / 24 h / 20 °C

10.1: copper(I) oxide / 1-methyl-pyrrolidin-2-one / 0.25 h / 190 °C / Inert atmosphere; Sealed vial

With copper(I) oxide; N-Bromosuccinimide; water; hydrogen; boron tribromide; potassium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5% rhodium-on-charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;