methyl 2-((1S,3S,5R)-1-(4-chlorophenyl)-5-isopropyl-7-oxo-3-phenylhexahydropyrazolo[1,2-a]pyrazol-1-yl)acetate

Base Information

Chemical Name:methyl 2-((1S,3S,5R)-1-(4-chlorophenyl)-5-isopropyl-7-oxo-3-phenylhexahydropyrazolo[1,2-a]pyrazol-1-yl)acetate
CAS No.:1537904-38-3
Molecular Formula:C₂₄H₂₇ClN₂O₃
Molecular Weight:426.943
Hs Code.:

Synonyms:methyl 2-((1S,3S,5R)-1-(4-chlorophenyl)-5-isopropyl-7-oxo-3-phenylhexahydropyrazolo[1,2-a]pyrazol-1-yl)acetate

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Chemical Property of methyl 2-((1S,3S,5R)-1-(4-chlorophenyl)-5-isopropyl-7-oxo-3-phenylhexahydropyrazolo[1,2-a]pyrazol-1-yl)acetate

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Technology Process of methyl 2-((1S,3S,5R)-1-(4-chlorophenyl)-5-isopropyl-7-oxo-3-phenylhexahydropyrazolo[1,2-a]pyrazol-1-yl)acetate

There total 2 articles about methyl 2-((1S,3S,5R)-1-(4-chlorophenyl)-5-isopropyl-7-oxo-3-phenylhexahydropyrazolo[1,2-a]pyrazol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1537904-33-8
(3R,5S)-7-(4-chlorophenyl)-3-isopropyl-5-phenyl-2,3,5,6-tetrahydropyrazolo[1,2-a][1,2]diazepine-1,9-dione

: 1537904-38-3
methyl 2-((1S,3S,5R)-1-(4-chlorophenyl)-5-isopropyl-7-oxo-3-phenylhexahydropyrazolo[1,2-a]pyrazol-1-yl)acetate

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; Schlenk technique; Inert atmosphere;
DOI:10.1021/ja411110f

Reference yield:

: 3-(4-chlorophenyl)-2-buten-1-al

: 14776-35-3
all-syn-1-benzylidene-3-oxo-5-phenylpyrazolidin-1-ium-2-ide

: 1537904-38-3
methyl 2-((1S,3S,5R)-1-(4-chlorophenyl)-5-isopropyl-7-oxo-3-phenylhexahydropyrazolo[1,2-a]pyrazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: (5aR,10bS)-2-mesityl-5a,10b-dihydro-4H,6H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate; potassium carbonate; 3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone / dichloromethane; tetrahydrofuran / 96 h / 20 °C / Inert atmosphere; Molecular sieve; Schlenk technique

2: sodium hydroxide / methanol / 20 °C / Schlenk technique; Inert atmosphere

With (5aR,10bS)-2-mesityl-5a,10b-dihydro-4H,6H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate; 3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja411110f