5-cyano-6-methylnicotinic acid

Base Information

• Chemical Name: 5-cyano-6-methylnicotinic acid
• CAS No.: 1216866-96-4
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.148
• Mol file: 1216866-96-4.mol

Synonyms:5-cyano-6-methylnicotinic acid

Chemical Property of 5-cyano-6-methylnicotinic acid

Chemical Property:

Purity/Quality:

99%min. ^*data from raw suppliers

5-Cyano-6-methylnicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-cyano-6-methylnicotinic acid

There total 4 articles about 5-cyano-6-methylnicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

→ 5-cyano-6-methylnicotinic acid (1216866-96-4)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield: 50.3%

5-cyano-6-methylnicotinic acid ethyl ester (106944-54-1) → 5-cyano-6-methylnicotinic acid (1216866-96-4)

Guidance literature:

5-cyano-6-methylnicotinic acid ethyl ester; With lithium hydroxide; In tetrahydrofuran; methanol; water; at 60 ℃; for 2h;

With hydrogenchloride; In water;

DOI:10.1021/jm500432n

Reference yield:

2-chloro-5-cyano-6-methyl-pyridine-3-carboxylic acid ethyl ester (75894-43-8) → 5-cyano-6-methylnicotinic acid (1216866-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; ammonium formate / methanol / 3 h / 20 °C

2: sodium hydroxide; water / methanol / 0.5 h / 20 °C

With palladium 10% on activated carbon; water; ammonium formate; sodium hydroxide; In methanol;

upstream raw materials:

5-cyano-6-methylnicotinic acid ethyl ester

2-chloro-5-cyano-6-methyl-pyridine-3-carboxylic acid ethyl ester

5-cyano-2-hydroxy-6-methylnicotinic acid ethyl ester

Refernces

• 1、 -. "NOVEL COMPOUNDS". Page/Page column 25. . Retrieved 2015/12/17.
• 2、 -. "NOVEL COMPOUNDS". Page/Page column 74; 75. . Retrieved 2015/12/17.