N-[1-(2,3-dimethoxy-benzylcarbamoyl)-2-(4-methoxy-phenyl)-ethyl]-2,3-dimethoxy-benzamide

Base Information

Chemical Name:N-[1-(2,3-dimethoxy-benzylcarbamoyl)-2-(4-methoxy-phenyl)-ethyl]-2,3-dimethoxy-benzamide
CAS No.:857064-55-2
Molecular Formula:C₂₈H₃₂N₂O₇
Molecular Weight:508.571
Hs Code.:

<i>N</i>-[1-(2,3-dimethoxy-benzylcarbamoyl)-2-(4-methoxy-phenyl)-ethyl]-2,3-dimethoxy-benzamide

Synonyms:N-[1-(2,3-dimethoxy-benzylcarbamoyl)-2-(4-methoxy-phenyl)-ethyl]-2,3-dimethoxy-benzamide

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Chemical Property of N-[1-(2,3-dimethoxy-benzylcarbamoyl)-2-(4-methoxy-phenyl)-ethyl]-2,3-dimethoxy-benzamide

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Technology Process of N-[1-(2,3-dimethoxy-benzylcarbamoyl)-2-(4-methoxy-phenyl)-ethyl]-2,3-dimethoxy-benzamide

There total 4 articles about N-[1-(2,3-dimethoxy-benzylcarbamoyl)-2-(4-methoxy-phenyl)-ethyl]-2,3-dimethoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 857064-50-7
2-amino-N-(2,3-dimethoxy-benzyl)-3-(4-methoxy-phenyl)-propionamide

: 1521-38-6
2,3-dimethoxybenzoic acid

: 857064-55-2
N-[1-(2,3-dimethoxy-benzylcarbamoyl)-2-(4-methoxy-phenyl)-ethyl]-2,3-dimethoxy-benzamide

Guidance literature:: 2,3-dimethoxybenzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 0.333333h;

2-amino-N-(2,3-dimethoxy-benzyl)-3-(4-methoxy-phenyl)-propionamide; In acetonitrile; at 20 ℃; for 48h;
DOI:10.1055/s-2005-861865

Reference yield:

: 857064-46-1
[1-(2,3-dimethoxy-benzylcarbamoyl)-2-(4-methoxy-phenyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

: 857064-55-2
N-[1-(2,3-dimethoxy-benzylcarbamoyl)-2-(4-methoxy-phenyl)-ethyl]-2,3-dimethoxy-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 91 percent / piperidine / acetonitrile / 24 h / 20 °C

2.1: HBTU; (i-Pr)2NEt / acetonitrile / 0.33 h / 20 °C

2.2: 87 percent / acetonitrile / 48 h / 20 °C

With piperidine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1055/s-2005-861865

Reference yield:

: 4393-09-3
2,3-dimethoxybenzyl amine

: 857064-55-2
N-[1-(2,3-dimethoxy-benzylcarbamoyl)-2-(4-methoxy-phenyl)-ethyl]-2,3-dimethoxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: HBTU; (i-Pr)2NEt / acetonitrile / 0.33 h / 20 °C

1.2: 82 percent / acetonitrile / 20 °C

2.1: 91 percent / piperidine / acetonitrile / 24 h / 20 °C

3.1: HBTU; (i-Pr)2NEt / acetonitrile / 0.33 h / 20 °C

3.2: 87 percent / acetonitrile / 48 h / 20 °C

With piperidine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1055/s-2005-861865