N-(2,6-dimethylphenyl)-N'-(4-methyl-2-phenylethynyl)thiourea

Base Information

• Chemical Name: N-(2,6-dimethylphenyl)-N'-(4-methyl-2-phenylethynyl)thiourea
• CAS No.: 215589-13-2
• Molecular Formula: C₂₄H₂₂N₂S
• Molecular Weight: 370.518
• Mol file: 215589-13-2.mol

Synonyms:N-(2,6-dimethylphenyl)-N'-(4-methyl-2-phenylethynyl)thiourea

Chemical Property of N-(2,6-dimethylphenyl)-N'-(4-methyl-2-phenylethynyl)thiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,6-dimethylphenyl)-N'-(4-methyl-2-phenylethynyl)thiourea

There total 1 articles about N-(2,6-dimethylphenyl)-N'-(4-methyl-2-phenylethynyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-methyl-2-(phenylethynyl)aniline (13141-44-1) + 2,6-dimethylphenylisothiocyanate (19241-16-8) → N-(2,6-dimethylphenyl)-N'-(4-methyl-2-phenylethynyl)thiourea (215589-13-2)

Guidance literature:

In acetone; for 16h; Heating;

DOI:10.1002/(SICI)1521-3773(19980918)37:17<2371::AID-ANIE2371>3.0.CO;2-N

Reference yield: 86.0%

N-(2,6-dimethylphenyl)-N'-(4-methyl-2-phenylethynyl)thiourea (215589-13-2) → N-(2,6-dimethylphenyl)-N'-[4-methyl-2-(phenylethynyl)phenyl]carbodiimide (215589-21-2)

Guidance literature:

With dmap; methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 0.0833333h;

DOI:10.1002/(SICI)1521-3773(19980918)37:17<2371::AID-ANIE2371>3.0.CO;2-N

Reference yield:

N-(2,6-dimethylphenyl)-N'-(4-methyl-2-phenylethynyl)thiourea (215589-13-2) → 4,9-dimethyl-11-phenyl-6H-indolo[2,3-b]quinoline

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / Et₃N; DMAP; MeSO₂Cl / CH₂Cl₂ / 0.17 h / 0 °C

2: 83 percent / toluene / 1 h / 20 °C / Irradiation

With dmap; methanesulfonyl chloride; triethylamine; In dichloromethane; toluene;

DOI:10.3390/51201372

upstream raw materials:

4-methyl-2-(phenylethynyl)aniline

2,6-dimethylphenylisothiocyanate

Downstream raw materials:

N-(2,6-dimethylphenyl)-N'-[4-methyl-2-(phenylethynyl)phenyl]carbodiimide