N-[1-(3-Cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-4-methyl-benzenesulfonamide

Base Information

• Chemical Name: N-[1-(3-Cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-4-methyl-benzenesulfonamide
• CAS No.: 80972-13-0
• Molecular Formula: C₂₂H₂₅N₃O₃S
• Molecular Weight: 411.525
• Mol file: 80972-13-0.mol

Synonyms:N-[1-(3-Cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-4-methyl-benzenesulfonamide

Chemical Property of N-[1-(3-Cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-4-methyl-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[1-(3-Cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-4-methyl-benzenesulfonamide

There total 4 articles about N-[1-(3-Cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

piperidine (110-89-4) + 3-(3-Cyano-phenyl)-3-(toluene-4-sulfonylamino)-propionyl chloride (80972-03-8) → N-[1-(3-Cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-4-methyl-benzenesulfonamide (80972-13-0)

Guidance literature:

In benzene; Ambient temperature;

Reference yield:

3-Cyanobenzaldehyde (24964-64-5) → N-[1-(3-Cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-4-methyl-benzenesulfonamide (80972-13-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 33 percent / CH₃COONH₄ / aq. ethanol / 4 h / Heating

2: 55 percent / KOH (1mol/l) / diethyl ether / 12 h / Ambient temperature

3: SOCl₂ / 1 h / Heating

4: 98 percent / benzene / Ambient temperature

With potassium hydroxide; thionyl chloride; ammonium acetate; In diethyl ether; ethanol; benzene;

Reference yield:

β-(m-Cyanphenyl)-β-alanin (80971-96-6,761396-82-1,791778-00-2) → N-[1-(3-Cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-4-methyl-benzenesulfonamide (80972-13-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 55 percent / KOH (1mol/l) / diethyl ether / 12 h / Ambient temperature

2: SOCl₂ / 1 h / Heating

3: 98 percent / benzene / Ambient temperature

With potassium hydroxide; thionyl chloride; In diethyl ether; benzene;

upstream raw materials:

piperidine

3-(3-Cyano-phenyl)-3-(toluene-4-sulfonylamino)-propionyl chloride

3-Cyanobenzaldehyde

β-(m-Cyanphenyl)-β-alanin

Downstream raw materials:

3-[3-Oxo-3-piperidin-1-yl-1-(toluene-4-sulfonylamino)-propyl]-benzamidine; hydriodide

3-[3-Oxo-3-piperidin-1-yl-1-(toluene-4-sulfonylamino)-propyl]-thiobenzimidic acid methyl ester; hydriodide

3-[3-Oxo-3-piperidin-1-yl-1-(toluene-4-sulfonylamino)-propyl]-thiobenzamide