(E)-tert-butyl 3-(3-chloro-2-fluoro-6-(2,2,2-trifluoroacetamido)phenyl)acrylate

Base Information

Chemical Name:(E)-tert-butyl 3-(3-chloro-2-fluoro-6-(2,2,2-trifluoroacetamido)phenyl)acrylate
CAS No.:1094106-60-1
Molecular Formula:C₁₅H₁₄ClF₄NO₃
Molecular Weight:367.728
Hs Code.:

Synonyms:(E)-tert-butyl 3-(3-chloro-2-fluoro-6-(2,2,2-trifluoroacetamido)phenyl)acrylate

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Chemical Property of (E)-tert-butyl 3-(3-chloro-2-fluoro-6-(2,2,2-trifluoroacetamido)phenyl)acrylate

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Technology Process of (E)-tert-butyl 3-(3-chloro-2-fluoro-6-(2,2,2-trifluoroacetamido)phenyl)acrylate

There total 3 articles about (E)-tert-butyl 3-(3-chloro-2-fluoro-6-(2,2,2-trifluoroacetamido)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1094106-59-8
N-(2-bromo-4-chloro-3-fluorophenyl)-2,2,2-trifluroacetamide

: 1094106-60-1
(E)-tert-butyl 3-(3-chloro-2-fluoro-6-(2,2,2-trifluoroacetamido)phenyl)acrylate

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; potassium carbonate; palladium diacetate; In N,N-dimethyl-formamide; at 110 ℃;

Reference yield:

: 367-22-6
4-chloro-3-fluoroaniline

: 1094106-60-1
(E)-tert-butyl 3-(3-chloro-2-fluoro-6-(2,2,2-trifluoroacetamido)phenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / diethyl ether / 1 h / -10 °C

2.1: tert.-butyl lithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; pentane / 1 h / -78 °C

2.2: 1.5 h

3.1: 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 110 °C

With 1,4-diaza-bicyclo[2.2.2]octane; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; palladium diacetate; sodium carbonate; potassium carbonate; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; pentane;
DOI:10.1021/acs.jmedchem.7b01171

Reference yield:

: 1094106-61-2
N-(4-chloro-3-fluorophenyl)-2,2,2-trifluoroacetamide

: 1094106-60-1
(E)-tert-butyl 3-(3-chloro-2-fluoro-6-(2,2,2-trifluoroacetamido)phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; pentane / 1 h / -78 °C

1.2: 1.5 h

2.1: 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 110 °C

With 1,4-diaza-bicyclo[2.2.2]octane; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; palladium diacetate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; pentane;
DOI:10.1021/acs.jmedchem.7b01171