[(5α,8β)-1-oxo-2-(4-(trifluoromethoxy)phenyl)-2-azaspiro[4.5]decan-8-yl]carbonochloridate

Base Information

• Chemical Name: [(5α,8β)-1-oxo-2-(4-(trifluoromethoxy)phenyl)-2-azaspiro[4.5]decan-8-yl]carbonochloridate
• CAS No.: 1292278-48-8
• Molecular Formula: C₁₇H₁₇ClF₃NO₄
• Molecular Weight: 391.774
• Mol file: 1292278-48-8.mol

Synonyms:[(5α,8β)-1-oxo-2-(4-(trifluoromethoxy)phenyl)-2-azaspiro[4.5]decan-8-yl]carbonochloridate

Chemical Property of [(5α,8β)-1-oxo-2-(4-(trifluoromethoxy)phenyl)-2-azaspiro[4.5]decan-8-yl]carbonochloridate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(5α,8β)-1-oxo-2-(4-(trifluoromethoxy)phenyl)-2-azaspiro[4.5]decan-8-yl]carbonochloridate

There total 6 articles about [(5α,8β)-1-oxo-2-(4-(trifluoromethoxy)phenyl)-2-azaspiro[4.5]decan-8-yl]carbonochloridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

bis(trichloromethyl) carbonate (32315-10-9) + (5α,8β)-8-hydroxy-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]decan-1-one (1292274-40-8) → [(5α,8β)-1-oxo-2-(4-(trifluoromethoxy)phenyl)-2-azaspiro[4.5]decan-8-yl]carbonochloridate (1292278-48-8)

Guidance literature:

With pyridine; In dichloromethane; at -10 - 0 ℃; for 2.08333h;

Reference yield:

ethyl 4-oxocyclohexane-1-carboxylate (17159-79-4) → [(5α,8β)-1-oxo-2-(4-(trifluoromethoxy)phenyl)-2-azaspiro[4.5]decan-8-yl]carbonochloridate (1292278-48-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / toluene / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran / 3.15 h / -5 - 0 °C

2.2: 12.5 h / -5 - 20 °C

3.1: hydrogenchloride; water / 2.75 h / 0 - 20 °C / pH 1

4.1: lithium tri-sec-butyl(hydrido)borate / tetrahydrofuran / 7 h / -78 °C

4.2: 1 h / 0 °C

5.1: toluene / 0.17 h / 20 °C

5.2: Reflux

6.1: pyridine / dichloromethane / 2.08 h / -10 - 0 °C

With pyridine; hydrogenchloride; water; toluene-4-sulfonic acid; lithium tri-sec-butyl(hydrido)borate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

1-(2-methoxy-ethyl)-4-oxo-cyclohexanecarboxylic acid ethyl ester (1292278-43-3) → [(5α,8β)-1-oxo-2-(4-(trifluoromethoxy)phenyl)-2-azaspiro[4.5]decan-8-yl]carbonochloridate (1292278-48-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium tri-sec-butyl(hydrido)borate / tetrahydrofuran / 7 h / -78 °C

1.2: 1 h / 0 °C

2.1: toluene / 0.17 h / 20 °C

2.2: Reflux

3.1: pyridine / dichloromethane / 2.08 h / -10 - 0 °C

With pyridine; lithium tri-sec-butyl(hydrido)borate; In tetrahydrofuran; dichloromethane; toluene;

upstream raw materials:

bis(trichloromethyl) carbonate

(5α,8β)-8-hydroxy-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]decan-1-one

ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

ethyl 4-oxocyclohexane-1-carboxylate

Downstream raw materials:

(5-methyl-pyrazin-2-ylmethyl)-carbamic acid [(5α,8β)-1-oxo-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]dec-8-yl] ester

(pyrazin-2-ylmethyl)-carbamic acid [(5α,8β)-1-oxo-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]dec-8-yl] ester