ethyl 2-[4-(2,2-dimethylpropoxy)-3-nitrophenyl]-4-methyl-1,3-thiazole-5-carboxylate

Base Information

Chemical Name:ethyl 2-[4-(2,2-dimethylpropoxy)-3-nitrophenyl]-4-methyl-1,3-thiazole-5-carboxylate
CAS No.:144060-72-0
Molecular Formula:C₁₈H₂₂N₂O₅S
Molecular Weight:378.449
Hs Code.:

Synonyms:ethyl 2-[4-(2,2-dimethylpropoxy)-3-nitrophenyl]-4-methyl-1,3-thiazole-5-carboxylate

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Chemical Property of ethyl 2-[4-(2,2-dimethylpropoxy)-3-nitrophenyl]-4-methyl-1,3-thiazole-5-carboxylate

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Technology Process of ethyl 2-[4-(2,2-dimethylpropoxy)-3-nitrophenyl]-4-methyl-1,3-thiazole-5-carboxylate

There total 4 articles about ethyl 2-[4-(2,2-dimethylpropoxy)-3-nitrophenyl]-4-methyl-1,3-thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 144060-72-0
ethyl 2-[4-(2,2-dimethylpropoxy)-3-nitrophenyl]-4-methyl-1,3-thiazole-5-carboxylate

: 144060-22-0
2-(4-neopentyloxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid

Guidance literature:

Reference yield:

: 20582-55-2
ethyl 4-methylthiazole-5-carboxylate

: 1365938-79-9
4-bromo-1-(2,2-dimethylpropoxy)-2-nitrobenzene

: 144060-72-0
ethyl 2-[4-(2,2-dimethylpropoxy)-3-nitrophenyl]-4-methyl-1,3-thiazole-5-carboxylate

Guidance literature:: With di-tert-butyl(cyclohexyl)phosphine; potassium hydrogencarbonate; isobutyric Acid; copper(I) bromide; palladium dichloride; In toluene; at 120 ℃; for 14h; Inert atmosphere;

Reference yield:

: 75-84-3
2,2-dimethyl-propanol-1

: 144060-72-0
ethyl 2-[4-(2,2-dimethylpropoxy)-3-nitrophenyl]-4-methyl-1,3-thiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium t-butanolate / toluene / 0.5 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: potassium hydrogencarbonate; palladium dichloride; copper(I) bromide; isobutyric Acid; di-tert-butyl(cyclohexyl)phosphine / toluene / 14 h / 120 °C / Inert atmosphere

With di-tert-butyl(cyclohexyl)phosphine; potassium hydrogencarbonate; isobutyric Acid; copper(I) bromide; palladium dichloride; sodium t-butanolate; In toluene;