9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-iodopurine

Base Information

Chemical Name:9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-iodopurine
CAS No.:756494-16-3
Molecular Formula:C₂₆H₂₃IN₄O₅
Molecular Weight:598.397
Hs Code.:

Synonyms:9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-iodopurine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-iodopurine

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Technology Process of 9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-iodopurine

There total 6 articles about 9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-iodopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 91713-46-1
6-Chloro-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)purine

: 756494-16-3
9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-iodopurine

Guidance literature:: With trifluoroacetic acid; sodium iodide; In butanone; at -50 - -40 ℃; for 5h;
DOI:10.1021/ol048987n

Reference yield: 61.0%

: 3056-12-0,3601-89-6,4330-21-6,52304-86-6,141846-57-3
2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythropentofuranosyl chloride

: 2545-26-8
6-iodopurine

: 756494-16-3
9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-iodopurine

Guidance literature:: With sodium hydride; In acetonitrile; at 20 ℃; for 18h;
DOI:10.1021/jo048812r

Reference yield:

: 890-38-0
2-deoxyinosine

: 756494-16-3
9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-iodopurine

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / pyridine / 2 h / 40 °C

2: 60 percent / POCl₃; benzyltriethylammonium chloride; N,N-dimethylaniline / acetonitrile / 0.17 h / 80 °C

3: 66 percent / NaI; TFA / butan-2-one / 5 h / -50 - -40 °C

With pyridine; N-benzyl-N,N,N-triethylammonium chloride; N,N-dimethyl-aniline; trifluoroacetic acid; sodium iodide; trichlorophosphate; In acetonitrile; butanone; 3: Finkelstein reaction;
DOI:10.1021/ol048987n