2-(2-tert-butoxycarbonylvinyl)-5-propoxybenzoic acid methyl ester

Base Information

Chemical Name:2-(2-tert-butoxycarbonylvinyl)-5-propoxybenzoic acid methyl ester
CAS No.:913648-40-5
Molecular Formula:C₁₈H₂₄O₅
Molecular Weight:320.386
Hs Code.:

Synonyms:2-(2-tert-butoxycarbonylvinyl)-5-propoxybenzoic acid methyl ester

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Chemical Property of 2-(2-tert-butoxycarbonylvinyl)-5-propoxybenzoic acid methyl ester

Chemical Property:

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Technology Process of 2-(2-tert-butoxycarbonylvinyl)-5-propoxybenzoic acid methyl ester

There total 4 articles about 2-(2-tert-butoxycarbonylvinyl)-5-propoxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913648-38-1
2-bromo-5-propoxy-benzoic acid methyl ester

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 913648-40-5
2-(2-tert-butoxycarbonylvinyl)-5-propoxybenzoic acid methyl ester

Guidance literature:: With triethylamine; tris-(o-tolyl)phosphine; dichloro bis(acetonitrile) palladium(II); In N,N-dimethyl-formamide; at 100 ℃; for 10h;
DOI:10.1016/j.tet.2006.07.075

Reference yield:

: 190965-43-6
2-bromo-5-propoxy-benzoic acid

: 913648-40-5
2-(2-tert-butoxycarbonylvinyl)-5-propoxybenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂SO₄ / 6 h / Heating

2: 5.3 g / P(o-tol)3; Et₃N / PdCl₂(MeCN)2 / dimethylformamide / 10 h / 100 °C

With sulfuric acid; triethylamine; tris-(o-tolyl)phosphine; dichloro bis(acetonitrile) palladium(II); In N,N-dimethyl-formamide; 2: Heck coupling;
DOI:10.1016/j.tet.2006.07.075

Reference yield:

: 2973-80-0
2-bromo-5-hydroxybenzaldehyde

: 913648-40-5
2-(2-tert-butoxycarbonylvinyl)-5-propoxybenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / ethanol; H₂O / 17 h / Heating

2: KMnO₄ / acetone; H₂O / 1.5 h / Heating

3: H₂SO₄ / 6 h / Heating

4: 5.3 g / P(o-tol)3; Et₃N / PdCl₂(MeCN)2 / dimethylformamide / 10 h / 100 °C

With potassium permanganate; sulfuric acid; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; dichloro bis(acetonitrile) palladium(II); In ethanol; water; N,N-dimethyl-formamide; acetone; 4: Heck coupling;
DOI:10.1016/j.tet.2006.07.075