1-[4-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)-piperidin-1-yl]-2-o-tolyl-ethanone

Base Information

Chemical Name:1-[4-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)-piperidin-1-yl]-2-o-tolyl-ethanone
CAS No.:1286708-30-2
Molecular Formula:C₂₀H₂₁N₃O₂S
Molecular Weight:367.472
Hs Code.:

Synonyms:1-[4-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)-piperidin-1-yl]-2-o-tolyl-ethanone

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Chemical Property of 1-[4-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)-piperidin-1-yl]-2-o-tolyl-ethanone

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Technology Process of 1-[4-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)-piperidin-1-yl]-2-o-tolyl-ethanone

There total 5 articles about 1-[4-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)-piperidin-1-yl]-2-o-tolyl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 4-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-piperidine hydrochloride

: 644-36-0
o-methylphenylacetic acid

: 1286708-30-2
1-[4-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)-piperidin-1-yl]-2-o-tolyl-ethanone

Guidance literature:: o-methylphenylacetic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; for 0.0833333h;

4-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-piperidine hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1021/jm200076a

Reference yield:

: 263383-22-8
4-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-piperidine-1-carboxylic acid tert-butyl ester

: 1286708-30-2
1-[4-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)-piperidin-1-yl]-2-o-tolyl-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.08 h

2.2: 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm200076a

Reference yield:

: 1003-31-2
thiophene-2-carbonitrile

: 1286708-30-2
1-[4-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)-piperidin-1-yl]-2-o-tolyl-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol / 4 h / Reflux

2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h

2.2: 2 h / 20 °C

3.1: N,N-dimethyl-formamide / 120 °C

4.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.08 h

5.2: 20 °C

With hydrogenchloride; hydroxylamine hydrochloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200076a