5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide

Base Information

Chemical Name:5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
CAS No.:1417658-57-1
Molecular Formula:C₁₈H₁₆FN₃O₂S
Molecular Weight:357.408
Hs Code.:

Synonyms:5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide

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Chemical Property of 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide

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Technology Process of 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide

There total 3 articles about 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 79-19-6
thiosemicarbazide

: 93637-98-0
(E)-3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-(4-fluoro-phenyl)-propenone

: 1417658-57-1
5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide

Guidance literature:: With potassium hydroxide; In ethanol; for 12h; Reflux;
DOI:10.1039/c4ra02200a

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 1417658-57-1
5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 24 h / Reflux

2: potassium hydroxide / ethanol; water / 20 °C

3: potassium hydroxide / ethanol / 12 h / Reflux

With potassium carbonate; potassium hydroxide; In ethanol; water; acetonitrile;
DOI:10.1016/j.bmc.2012.11.020

Reference yield:

: 29668-44-8
2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde

: 1417658-57-1
5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol; water / 20 °C

2: potassium hydroxide / ethanol / 12 h / Reflux

With potassium hydroxide; In ethanol; water;
DOI:10.1016/j.bmc.2012.11.020