2-(5-(((2-(dimethylamino)ethyl)(methyl)amino)methyl)-2-hydroxybenzamido)-4-phenylbenzoic acid

Base Information

Chemical Name:2-(5-(((2-(dimethylamino)ethyl)(methyl)amino)methyl)-2-hydroxybenzamido)-4-phenylbenzoic acid
CAS No.:1237515-89-7
Molecular Formula:C₂₆H₂₉N₃O₄
Molecular Weight:447.534
Hs Code.:

Synonyms:2-(5-(((2-(dimethylamino)ethyl)(methyl)amino)methyl)-2-hydroxybenzamido)-4-phenylbenzoic acid

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Chemical Property of 2-(5-(((2-(dimethylamino)ethyl)(methyl)amino)methyl)-2-hydroxybenzamido)-4-phenylbenzoic acid

Chemical Property:

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Technology Process of 2-(5-(((2-(dimethylamino)ethyl)(methyl)amino)methyl)-2-hydroxybenzamido)-4-phenylbenzoic acid

There total 7 articles about 2-(5-(((2-(dimethylamino)ethyl)(methyl)amino)methyl)-2-hydroxybenzamido)-4-phenylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1237520-19-2
tert-butyl 2-(5-(((2-(dimethylamino)ethyl)(methyl)amino)methyl)-2-(methoxymethoxy)benzamido)-4-phenylbenzoate

: 1237515-89-7
2-(5-(((2-(dimethylamino)ethyl)(methyl)amino)methyl)-2-hydroxybenzamido)-4-phenylbenzoic acid

Guidance literature:: tert-butyl 2-(5-(((2-(dimethylamino)ethyl)(methyl)amino)methyl)-2-(methoxymethoxy)benzamido)-4-phenylbenzoate; With trifluoroacetic acid; at 20 ℃; for 8h;

With sodium hydrogencarbonate; In water; ethyl acetate; pH=6.3;

Reference yield:

: 14504-08-6
2-acetoxy-5-methylbenzoic acid

: 1237515-89-7
2-(5-(((2-(dimethylamino)ethyl)(methyl)amino)methyl)-2-hydroxybenzamido)-4-phenylbenzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2.1: pyridine / dichloromethane / 1 h / 20 °C / Cooling with ice

3.1: methanol; potassium carbonate / 2.5 h / 20 °C

4.1: potassium carbonate / acetone / 4.83 h / 20 °C / Reflux

5.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / benzene / 0.5 h / Reflux

6.1: acetone / 1 h / 20 °C / Cooling with ice

7.1: trifluoroacetic acid / 8 h / 20 °C

7.2: pH 6.3

With pyridine; methanol; N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); potassium carbonate; trifluoroacetic acid; N,N-dimethyl-formamide; In dichloromethane; acetone; benzene;

Reference yield:

: 1237515-64-8
tert-butyl 2-(2-hydroxy-5-methylbenzamido)-4-phenylbenzoate

: 1237515-89-7
2-(5-(((2-(dimethylamino)ethyl)(methyl)amino)methyl)-2-hydroxybenzamido)-4-phenylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 4.83 h / 20 °C / Reflux

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / benzene / 0.5 h / Reflux

3.1: acetone / 1 h / 20 °C / Cooling with ice

4.1: trifluoroacetic acid / 8 h / 20 °C

4.2: pH 6.3

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; trifluoroacetic acid; In acetone; benzene;