N-methyl-2-(2-(2-(3-oxo-4-phenylpiperazino)propoxy)phenyl)thiazolidine-3-carbothioamide

Base Information

Chemical Name:N-methyl-2-(2-(2-(3-oxo-4-phenylpiperazino)propoxy)phenyl)thiazolidine-3-carbothioamide
CAS No.:111154-00-8
Molecular Formula:C₂₄H₃₀N₄O₂S₂
Molecular Weight:470.66
Hs Code.:

Synonyms:N-methyl-2-(2-(2-(3-oxo-4-phenylpiperazino)propoxy)phenyl)thiazolidine-3-carbothioamide

Suppliers and Price of N-methyl-2-(2-(2-(3-oxo-4-phenylpiperazino)propoxy)phenyl)thiazolidine-3-carbothioamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-methyl-2-(2-(2-(3-oxo-4-phenylpiperazino)propoxy)phenyl)thiazolidine-3-carbothioamide

Chemical Property:

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Technology Process of N-methyl-2-(2-(2-(3-oxo-4-phenylpiperazino)propoxy)phenyl)thiazolidine-3-carbothioamide

There total 6 articles about N-methyl-2-(2-(2-(3-oxo-4-phenylpiperazino)propoxy)phenyl)thiazolidine-3-carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.3%

: 90917-86-5
1-phenyl-2-piperazinone

: 103076-37-5
2-[2-(3-Chloro-propoxy)-phenyl]-thiazolidine-3-carbothioic acid methylamide

: 111154-00-8
N-methyl-2-(2-(2-(3-oxo-4-phenylpiperazino)propoxy)phenyl)thiazolidine-3-carbothioamide

Guidance literature:: With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1248/cpb.35.2825

Reference yield:

: 1664-40-0
N-(2-aminoethyl)benzeneamine

: 111154-00-8
N-methyl-2-(2-(2-(3-oxo-4-phenylpiperazino)propoxy)phenyl)thiazolidine-3-carbothioamide

Guidance literature:: Multi-step reaction with 5 steps

1: NEt₃ / tetrahydrofuran

2: 10percent aq. NaOH / ethyl acetate

3: K₂CO₃ / tetrahydrofuran / 48 h / Ambient temperature

4: 22.9 percent / HCO₂NH₄ / 10percent Pd-C / methanol / 0.17 h / Ambient temperature

5: 38.3 percent / K₂CO₃, NaI / dimethylformamide / 80 °C

With sodium hydroxide; ammonium formate; potassium carbonate; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.2825

Reference yield:

: 111153-98-1
3-Oxo-4-phenyl-piperazine-1-carbaldehyde

: 111154-00-8
N-methyl-2-(2-(2-(3-oxo-4-phenylpiperazino)propoxy)phenyl)thiazolidine-3-carbothioamide

Guidance literature:: Multi-step reaction with 2 steps

1: 92.8 percent / conc. HCl / methanol / Heating

2: 38.3 percent / K₂CO₃, NaI / dimethylformamide / 80 °C

With hydrogenchloride; potassium carbonate; sodium iodide; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.2825