Chemical Property of Osthole
Chemical Property:
- Appearance/Colour:Fine White Powder
- Vapor Pressure:1.67E-06mmHg at 25°C
- Melting Point:83-84 °C
- Refractive Index:1.556
- Boiling Point:396.7 °C at 760 mmHg
- Flash Point:167.6 °C
- PSA：39.44000
- Density:1.126 g/cm3
- LogP:3.31030
- Storage Temp.:room temp
- Solubility.:methanol: soluble10mg/mL, clear, colorless
- Water Solubility.:12mg/L(25 oC)
- XLogP3:3.8
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:3
- Exact Mass:244.109944368
- Heavy Atom Count:18
- Complexity:366
- Purity/Quality:
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98%, *data from raw suppliers
Osthol *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi,
Xn
- Hazard Codes:Xi,Xn
- MSDS Files:
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Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C
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Description
Cnidium is a Chinese medicine which is used widely by traditional medicine doctors.
Cnidium has been recorded in almost all of the pharmaceutical monographs , including Shen Nong’s Classic Materia Medica, New Materia Medica, Compendium of Materia Medica, etc. Osthole is a major bioactivity compound of the Cnidium, which has the effect of dampness dispelling, insecticidal antipruritic,and aphrodisiac and is used for the treatment for pruritus and eczema, lumbago,kidney impotence, and infertility .
Osthole is derived from Umbelliferae and Rutaceae plants. Osthole is also distributed
in Asteraceae and Leguminosae plants. Osthole is present in 14 genera of Umbelliferae plants: danggui (Angelica L.), gudanggui (Archangelica Hoffm.), mianguoqin (Cachrys L.), shechuang (Cnidium Cusson), awei (Ferula L.), duhuo (Heracleum L.), yanfeng (Libanotis Hill), ouqin (Petroselinum Hill), qianhu (Peucedanum L.), huiqin (Pimpinella L.), liangshechuang (Selinum L.). Shuanchiqin (Prangos Lindl), xifengqin (Seseli L.), oufangfeng (Pastinaca L.). Osthole is present in 17 genera of Rutaceae plants: ganju (Citrus L.), huangpi (Clausena Burm. F.), xiangju (Feronia Correa), jupanmu (Flindersia R. Br.), niyunxiang (Haplophyllum A. Juss.), mizhuyu (Melicope J. R. and G. Forst.), xiaoyunmu (Micromelum Bl.), jiulixiang (Murraya Koenig ex L.), zhi (Poncirus Raf.), yinyu (Skimmia Thunb.), Limonia, Myrtopsis, Pentaceras, Phebalium, Pilocarpus, Thamnosma, Ticorea) .
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Physical properties
Appearance: white needlelike crystalline powder. Solubility: soluble in methanol.
Melting point: 83–84 °C.
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Uses
Osthole inhibits the PI3K/Akt pathway thus inhibiting insulin-like growth factor-1 (IGF-1)-induced epithelial-to-mesenchymal transition (EMT) in brain cancer. Osthole may be used in the treatment of Glioblastoma multiforme (GBM).
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Indications
Impotence, infertility, uterine cold, wet nose with low back pain, vulva eczema,
woman vulvae, trichomonas vaginitis
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Clinical Use
In vitro and in vivo experimental results have revealed that osthole demonstrates
multiple pharmacological actions including neuroprotective, osteogenic, immunomodulatory,anticancer, hepatoprotective, cardiovascular protective, and antimicrobial activities. Osthole is expected to be used in the treatment of cardiovascular system, central nervous system, and immune system diseases.
