{4-[4-(4-methylpiperazin-1-yl)phenyl]thiazol-2-yl}-(6-methylpyridin-2-yl)amine hydrochloride salt

Base Information

Chemical Name:{4-[4-(4-methylpiperazin-1-yl)phenyl]thiazol-2-yl}-(6-methylpyridin-2-yl)amine hydrochloride salt
CAS No.:1426259-46-2
Molecular Formula:C₂₀H₂₃N₅S*ClH
Molecular Weight:401.963
Hs Code.:

Synonyms:{4-[4-(4-methylpiperazin-1-yl)phenyl]thiazol-2-yl}-(6-methylpyridin-2-yl)amine hydrochloride salt

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Chemical Property of {4-[4-(4-methylpiperazin-1-yl)phenyl]thiazol-2-yl}-(6-methylpyridin-2-yl)amine hydrochloride salt

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Technology Process of {4-[4-(4-methylpiperazin-1-yl)phenyl]thiazol-2-yl}-(6-methylpyridin-2-yl)amine hydrochloride salt

There total 5 articles about {4-[4-(4-methylpiperazin-1-yl)phenyl]thiazol-2-yl}-(6-methylpyridin-2-yl)amine hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.4%

: 109-01-3
1-methyl-piperazine

: 1310049-89-8
[4-(4-bromophenyl)-1,3-thiazol-2-yl]-(6-methylpyridin-2-yl)amine

: 1426259-46-2
{4-[4-(4-methylpiperazin-1-yl)phenyl]thiazol-2-yl}-(6-methylpyridin-2-yl)amine hydrochloride salt

Guidance literature:: 1-methyl-piperazine; [4-(4-bromophenyl)-1,3-thiazol-2-yl]-(6-methylpyridin-2-yl)amine; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In N,N-dimethyl-formamide; at 140 ℃; for 1h; Inert atmosphere; Microwave irradiation;

With hydrogenchloride; In methanol; diethyl ether; dichloromethane; Inert atmosphere;
DOI:10.1002/cmdc.201300007

Reference yield:

: 96938-51-1
N-(6-methylpyridine-2-ylcarbamothioyl)benzamide

: 1426259-46-2
{4-[4-(4-methylpiperazin-1-yl)phenyl]thiazol-2-yl}-(6-methylpyridin-2-yl)amine hydrochloride salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol / 0.5 h / Reflux

2.1: ethanol / 3 h / Reflux

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / N,N-dimethyl-formamide / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

3.2: Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; sodium t-butanolate; In methanol; ethanol; N,N-dimethyl-formamide; 2.1: |Hantzsch Thiazole Synthesis / 3.1: |Buchwald-Hartwig Coupling;
DOI:10.1002/cmdc.201300007

Reference yield:

: 49600-34-2
(6-methyl-pyridin-2-yl)-thiourea

: 1426259-46-2
{4-[4-(4-methylpiperazin-1-yl)phenyl]thiazol-2-yl}-(6-methylpyridin-2-yl)amine hydrochloride salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 3 h / Reflux

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / N,N-dimethyl-formamide / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

2.2: Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In ethanol; N,N-dimethyl-formamide; 1.1: |Hantzsch Thiazole Synthesis / 2.1: |Buchwald-Hartwig Coupling;
DOI:10.1002/cmdc.201300007