tert-butyl (R)-4-(4-chloro-3-hydroxyphenyl)-2-oxopyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (R)-4-(4-chloro-3-hydroxyphenyl)-2-oxopyrrolidine-1-carboxylate
CAS No.:1252762-31-4
Molecular Formula:C₁₅H₁₈ClNO₄
Molecular Weight:311.765
Hs Code.:

Synonyms:tert-butyl (R)-4-(4-chloro-3-hydroxyphenyl)-2-oxopyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (R)-4-(4-chloro-3-hydroxyphenyl)-2-oxopyrrolidine-1-carboxylate

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Technology Process of tert-butyl (R)-4-(4-chloro-3-hydroxyphenyl)-2-oxopyrrolidine-1-carboxylate

There total 13 articles about tert-butyl (R)-4-(4-chloro-3-hydroxyphenyl)-2-oxopyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1252761-96-8
tert-butyl (4R)-4-[4-chloro-3-(4,4,5,5-tetramethyl(1,3,2-dioxaborolan-2-yl))phenyl]-2-oxopyrrolidinecarboxylate

: 1252762-31-4
tert-butyl (R)-4-(4-chloro-3-hydroxyphenyl)-2-oxopyrrolidine-1-carboxylate

Guidance literature:: With dihydrogen peroxide; In dichloromethane; at 20 ℃;

Reference yield: 80.0%

: tert-butyl (R)-4-(3-(benzyloxy)-4-chlorophenyl)-2-oxopyrrolidine-1-carboxylate

: 1252762-31-4
tert-butyl (R)-4-(4-chloro-3-hydroxyphenyl)-2-oxopyrrolidine-1-carboxylate

Guidance literature:: With palladium hydroxide, 20 wt% on carbon; hydrogen; In methanol; at 20 ℃; for 0.5h; under 2585.81 Torr;
DOI:10.1021/acschemneuro.8b00038

Reference yield:

: 1252761-21-9
(R)-4-(3-amino-4-chlorophenyl)pyrrolidin-2-one

: 1252762-31-4
tert-butyl (R)-4-(4-chloro-3-hydroxyphenyl)-2-oxopyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; potassium iodide; sodium nitrite / water / 0 °C

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane; dichloromethane

3: dihydrogen peroxide / dichloromethane

With hydrogenchloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; dihydrogen peroxide; potassium acetate; potassium iodide; sodium nitrite; In 1,4-dioxane; dichloromethane; water; 1: Sandmeyer reaction;
DOI:10.1016/j.bmcl.2011.08.006