(3-methyl-1-phenylacetyl-butyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (3-methyl-1-phenylacetyl-butyl)-carbamic acid tert-butyl ester
• CAS No.: 922722-23-4
• Molecular Formula: C₁₈H₂₇NO₃
• Molecular Weight: 305.417
• Mol file: 922722-23-4.mol

Synonyms:(3-methyl-1-phenylacetyl-butyl)-carbamic acid tert-butyl ester

Chemical Property of (3-methyl-1-phenylacetyl-butyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-methyl-1-phenylacetyl-butyl)-carbamic acid tert-butyl ester

There total 1 articles about (3-methyl-1-phenylacetyl-butyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-(tert-butoxycarbonyl)-L-leucine-N'-methoxy-N'-methylamide (87694-50-6) + benzylmagnesium chloride (6921-34-2) → (3-methyl-1-phenylacetyl-butyl)-carbamic acid tert-butyl ester (922722-23-4)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jm060754+

Reference yield: 92.0%

(3-methyl-1-phenylacetyl-butyl)-carbamic acid tert-butyl ester (922722-23-4) + ethyl (S,E)-4-[(ethoxycarbonyl)oxy]pent-2-enoate → C25H37NO5

Guidance literature:

(3-methyl-1-phenylacetyl-butyl)-carbamic acid tert-butyl ester; With zinc(II) chloride; lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 0.5h; Schlenk technique;

ethyl (S,E)-4-[(ethoxycarbonyl)oxy]pent-2-enoate; With bis(η3-allyl-μ-chloropalladium(II)); triphenylphosphine; In tetrahydrofuran; at 20 ℃; diastereoselective reaction; Schlenk technique;

DOI:10.1002/chem.202000051

Reference yield: 85.0%

(3-methyl-1-phenylacetyl-butyl)-carbamic acid tert-butyl ester (922722-23-4) + (S,E)-tert-butyl (5-oxohex-3-en-2-yl) carbonate → C24H35NO4

Guidance literature:

(3-methyl-1-phenylacetyl-butyl)-carbamic acid tert-butyl ester; With zinc(II) chloride; lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 0.5h; Schlenk technique;

(S,E)-tert-butyl (5-oxohex-3-en-2-yl) carbonate; With bis(η3-allyl-μ-chloropalladium(II)); triphenylphosphine; In tetrahydrofuran; at -25 ℃; diastereoselective reaction; Schlenk technique;

DOI:10.1002/chem.202000051

upstream raw materials:

N-(tert-butoxycarbonyl)-L-leucine-N'-methoxy-N'-methylamide

benzylmagnesium chloride

Downstream raw materials:

[1-(1-hydroxy-2-phenyl-ethyl)-3-methyl-butyl]-carbamic acid tert-butyl ester

[(S)-1-((S)-1-Hydroxy-2-phenyl-ethyl)-3-methyl-butyl]-carbamic acid tert-butyl ester

[(1S,2R)-2-azido-2-benzyl-1-isobutylethyl]carbamic acid tert-butyl ester

[(1S,2S)-2-azido-2-benzyl-1-isobutylethyl]carbamic acid tert-butyl ester