Technology Process of 2-(2-bromomethylphenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester
There total 5 articles about 2-(2-bromomethylphenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-Bromosuccinimide; dibenzoyl peroxide;
In
benzene;
for 0.333333h;
Inert atmosphere;
Reflux;
DOI:10.1021/ol901454y
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / diethyl ether / 18 h / Inert atmosphere; Reflux
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: L-proline / dimethyl sulfoxide / 16 h / Inert atmosphere
4.1: sodium hydride / dimethyl sulfoxide; mineral oil / Inert atmosphere
4.2: 9 h / Inert atmosphere
5.1: N-Bromosuccinimide; dibenzoyl peroxide / benzene / 0.33 h / Inert atmosphere; Reflux
With
N-Bromosuccinimide; lithium aluminium tetrahydride; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; L-proline; dibenzoyl peroxide;
In
diethyl ether; dichloromethane; dimethyl sulfoxide; mineral oil; benzene;
DOI:10.1021/ol901454y
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: L-proline / dimethyl sulfoxide / 16 h / Inert atmosphere
3.1: sodium hydride / dimethyl sulfoxide; mineral oil / Inert atmosphere
3.2: 9 h / Inert atmosphere
4.1: N-Bromosuccinimide; dibenzoyl peroxide / benzene / 0.33 h / Inert atmosphere; Reflux
With
N-Bromosuccinimide; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; L-proline; dibenzoyl peroxide;
In
dichloromethane; dimethyl sulfoxide; mineral oil; benzene;
DOI:10.1021/ol901454y
