1-(4-nitrobenzyl)triethylenetetraamine

Base Information

• Chemical Name: 1-(4-nitrobenzyl)triethylenetetraamine
• CAS No.: 262354-22-3
• Molecular Formula: C₁₃H₂₃N₅O₂
• Molecular Weight: 281.358
• Mol file: 262354-22-3.mol

Synonyms:1-(4-nitrobenzyl)triethylenetetraamine

Chemical Property of 1-(4-nitrobenzyl)triethylenetetraamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(4-nitrobenzyl)triethylenetetraamine

There total 4 articles about 1-(4-nitrobenzyl)triethylenetetraamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

glycyl-N-(2-aminoethyl)-4-nitrophenylalaninamide → 1-(4-nitrobenzyl)triethylenetetraamine (262354-22-3)

Guidance literature:

With tetrahydrofuran; borane; In tetrahydrofuran; for 36h; Heating;

DOI:10.1002/jlcr.1031

Reference yield:

[2-imidazol-1-yl-1-(4-nitro-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester → 1-(4-nitrobenzyl)triethylenetetraamine (262354-22-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.38 g / dimethylformamide / 12 h / 20 °C

2: aq. HCl / 8 h / 20 °C

3: 79 percent / BH₃/THF / tetrahydrofuran / 36 h / Heating

With tetrahydrofuran; hydrogenchloride; borane; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/jlcr.1031

Reference yield:

[1-[2-(2-tert-butoxycarbonylamino-acetylamino)-ethylcarbamoyl]-2-(4-nitro-phenyl)-ethyl]-carbamic acid tert-butyl ester → 1-(4-nitrobenzyl)triethylenetetraamine (262354-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl / 8 h / 20 °C

2: 79 percent / BH₃/THF / tetrahydrofuran / 36 h / Heating

With tetrahydrofuran; hydrogenchloride; borane; In tetrahydrofuran;

DOI:10.1002/jlcr.1031

upstream raw materials:

2-tert-butoxycarbonylamino-3-(4-nitro-phenyl)-propionic acid

Downstream raw materials:

{[2-[(2-{[2-(bis-tert-butoxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-ethyl)-tert-butoxycarbonylmethyl-amino]-1-(4-nitro-benzyl)-ethyl]-tert-butoxycarbonylmethyl-amino}-acetic acid tert-butyl ester