(S)-tert-butyl 1-((2S,3R)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)-2-hydroxy-5-methyhexyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 1-((2S,3R)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)-2-hydroxy-5-methyhexyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1415385-77-1
Molecular Formula:C₃₄H₄₆N₂O₈
Molecular Weight:610.748
Hs Code.:

(S)-tert-butyl 1-((2S,3R)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)-2-hydroxy-5-methyhexyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Synonyms:(S)-tert-butyl 1-((2S,3R)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)-2-hydroxy-5-methyhexyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of (S)-tert-butyl 1-((2S,3R)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)-2-hydroxy-5-methyhexyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Technology Process of (S)-tert-butyl 1-((2S,3R)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)-2-hydroxy-5-methyhexyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 9 articles about (S)-tert-butyl 1-((2S,3R)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)-2-hydroxy-5-methyhexyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₂₅NO₅

: C₂₄H₃₈BNO₃

: 1415385-77-1
(S)-tert-butyl 1-((2S,3R)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)-2-hydroxy-5-methyhexyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: C₁₈H₂₅NO₅; C₂₄H₃₈BNO₃; In dichloromethane; at -78 - 0 ℃; for 3h;

With dihydrogen peroxide; In methanol; dichloromethane; at 0 - 5 ℃; for 1h;
DOI:10.1016/j.tetlet.2012.10.017

Reference yield:

: (R)-N-(2-(2-chloroethyl)-4,5-dimethoxybenzylidene)-2-methylpropane-2-sulfinamide

: 1415385-77-1
(S)-tert-butyl 1-((2S,3R)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)-2-hydroxy-5-methyhexyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 6 h / 0 - 20 °C

3.1: hydrogenchloride / ethanol; 1,4-dioxane / 5 h / 0 °C

4.1: triethylamine / dichloromethane / 0.17 h

4.2: 1 h / 20 °C

5.1: osmium(VIII) oxide; 2,6-dimethylpyridine; sodium periodate / 1,4-dioxane / 2 h

6.1: dichloromethane / 3 h / -78 - 0 °C

6.2: 1 h / 0 - 5 °C

With 2,6-dimethylpyridine; hydrogenchloride; sodium periodate; osmium(VIII) oxide; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; 6.1: |Evans Aldol Reaction;
DOI:10.1016/j.tetlet.2012.10.017

Reference yield:

: 181220-97-3
(S)-1-allyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 1415385-77-1
(S)-tert-butyl 1-((2S,3R)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)-2-hydroxy-5-methyhexyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.17 h

1.2: 1 h / 20 °C

2.1: osmium(VIII) oxide; 2,6-dimethylpyridine; sodium periodate / 1,4-dioxane / 2 h

3.1: dichloromethane / 3 h / -78 - 0 °C

3.2: 1 h / 0 - 5 °C

With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; triethylamine; In 1,4-dioxane; dichloromethane; 3.1: |Evans Aldol Reaction;
DOI:10.1016/j.tetlet.2012.10.017