(±)-tert-butyl((1-benzylpiperidin-3-yl)methyl)(2-methoxyethyl)carbamate

Base Information

Chemical Name:(±)-tert-butyl((1-benzylpiperidin-3-yl)methyl)(2-methoxyethyl)carbamate
CAS No.:1585985-05-2
Molecular Formula:C₂₁H₃₄N₂O₃
Molecular Weight:362.513
Hs Code.:

Synonyms:(±)-tert-butyl((1-benzylpiperidin-3-yl)methyl)(2-methoxyethyl)carbamate

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Chemical Property of (±)-tert-butyl((1-benzylpiperidin-3-yl)methyl)(2-methoxyethyl)carbamate

Chemical Property:

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Technology Process of (±)-tert-butyl((1-benzylpiperidin-3-yl)methyl)(2-methoxyethyl)carbamate

There total 5 articles about (±)-tert-butyl((1-benzylpiperidin-3-yl)methyl)(2-methoxyethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1339097-59-4
(±)-N-((1-benzylpiperidin-3-yl)methyl)-2-methoxyethan-1-amine

: 1585985-05-2
(±)-tert-butyl((1-benzylpiperidin-3-yl)methyl)(2-methoxyethyl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 20h;
DOI:10.1016/j.tetlet.2014.02.034

Reference yield:

: 13850-76-5
(±)-1-benzoylpiperidine-3-carboxylic acid

: 1585985-05-2
(±)-tert-butyl((1-benzylpiperidin-3-yl)methyl)(2-methoxyethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 0.5 h / 20 °C

1.2: 22 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

3.1: triethylamine / dichloromethane / 20 h / 0 - 20 °C

With lithium aluminium tetrahydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2014.02.034

Reference yield:

: 498-95-3,262853-93-0
nipecotic acid

: 1585985-05-2
(±)-tert-butyl((1-benzylpiperidin-3-yl)methyl)(2-methoxyethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrahydrofuran; water / 22 h / 0 - 20 °C

1.2: 0 °C / pH 1 - 2

2.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 0.5 h / 20 °C

2.2: 22 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

4.1: triethylamine / dichloromethane / 20 h / 0 - 20 °C

With lithium aluminium tetrahydride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tetlet.2014.02.034