2-amino-4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid

Base Information

Chemical Name:2-amino-4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid
CAS No.:1312769-49-5
Molecular Formula:C₂₇H₃₄ClN₅O₆
Molecular Weight:560.05
Hs Code.:

Synonyms:2-amino-4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid

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Chemical Property of 2-amino-4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid

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Technology Process of 2-amino-4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid

There total 5 articles about 2-amino-4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312769-48-4
4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoic acid hydrochloride

: 1312769-49-5
2-amino-4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid

Guidance literature:: With acetic acid; zinc; In ethyl acetate; at 20 ℃; for 4.33333h; Cooling with ice;

Reference yield:

: 1312771-09-7
tert-butyl 4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoate

: 1312769-49-5
2-amino-4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: Lawessons reagent / tetrahydrofuran / 16 h / Cooling with ice

2: triethylamine; mercury(II) diacetate / tetrahydrofuran; methanol / 1.5 h / Cooling with ice

3: hydrogenchloride / ethyl acetate / 4 h / 20 °C

4: zinc; acetic acid / ethyl acetate / 4.33 h / 20 °C / Cooling with ice

With Lawessons reagent; hydrogenchloride; mercury(II) diacetate; acetic acid; triethylamine; zinc; In tetrahydrofuran; methanol; ethyl acetate;

Reference yield:

: 1312770-12-9
tert-butyl 4-[(1R)-1-isocyanatobutyl]-2-nitrobenzoate

: 1312769-49-5
2-amino-4-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium tert-butylate / acetonitrile; tetrahydrofuran / 0.5 h / Cooling with ice

2: Lawessons reagent / tetrahydrofuran / 16 h / Cooling with ice

3: triethylamine; mercury(II) diacetate / tetrahydrofuran; methanol / 1.5 h / Cooling with ice

4: hydrogenchloride / ethyl acetate / 4 h / 20 °C

5: zinc; acetic acid / ethyl acetate / 4.33 h / 20 °C / Cooling with ice

With Lawessons reagent; hydrogenchloride; potassium tert-butylate; mercury(II) diacetate; acetic acid; triethylamine; zinc; In tetrahydrofuran; methanol; ethyl acetate; acetonitrile;