trans-N-{2-oxo-2-[3-(trifluoromethyl)phenyl]ethyl}(4-{[(phenylmethoxy)carbonylamino]methyl}cyclohexyl)carboxamide

Base Information

Chemical Name:trans-N-{2-oxo-2-[3-(trifluoromethyl)phenyl]ethyl}(4-{[(phenylmethoxy)carbonylamino]methyl}cyclohexyl)carboxamide
CAS No.:519058-32-3
Molecular Formula:C₂₅H₂₇F₃N₂O₄
Molecular Weight:476.496
Hs Code.:

Synonyms:trans-N-{2-oxo-2-[3-(trifluoromethyl)phenyl]ethyl}(4-{[(phenylmethoxy)carbonylamino]methyl}cyclohexyl)carboxamide

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Chemical Property of trans-N-{2-oxo-2-[3-(trifluoromethyl)phenyl]ethyl}(4-{[(phenylmethoxy)carbonylamino]methyl}cyclohexyl)carboxamide

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Technology Process of trans-N-{2-oxo-2-[3-(trifluoromethyl)phenyl]ethyl}(4-{[(phenylmethoxy)carbonylamino]methyl}cyclohexyl)carboxamide

There total 1 articles about trans-N-{2-oxo-2-[3-(trifluoromethyl)phenyl]ethyl}(4-{[(phenylmethoxy)carbonylamino]methyl}cyclohexyl)carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27687-12-3
(1r,4r)-4-({[(benzyloxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid

: 61062-56-4
2-amino-1-(3-(trifluoromethyl)phenyl)ethan-1-one hydrochloride

: 519058-32-3
trans-N-{2-oxo-2-[3-(trifluoromethyl)phenyl]ethyl}(4-{[(phenylmethoxy)carbonylamino]methyl}cyclohexyl)carboxamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1021/jm030490g

Reference yield:

: 519058-32-3
trans-N-{2-oxo-2-[3-(trifluoromethyl)phenyl]ethyl}(4-{[(phenylmethoxy)carbonylamino]methyl}cyclohexyl)carboxamide

: 519058-34-5
trans-(4-{4-[3-(trifluoromethyl)phenyl]imidazol-2-yl}cyclohexyl)methylamine

Guidance literature:: Multi-step reaction with 2 steps

1: AcOH; NH₄OAc / 16 h / Heating

2: H₂ / Pd/C / ethanol / 2844.31 Torr

With ammonium acetate; hydrogen; acetic acid; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm030490g

Reference yield:

: 519058-32-3
trans-N-{2-oxo-2-[3-(trifluoromethyl)phenyl]ethyl}(4-{[(phenylmethoxy)carbonylamino]methyl}cyclohexyl)carboxamide

: N-methyl-N-{4-[4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-cyclohexylmethyl}-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: AcOH; NH₄OAc / 16 h / Heating

2.1: H₂ / Pd/C / ethanol / 2844.31 Torr

3.1: triethylamine / CH₂Cl₂ / 2 h / 20 °C

4.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.08 h / 20 °C

4.2: 40 percent / tetrahydrofuran

With ammonium acetate; hydrogen; sodium hexamethyldisilazane; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm030490g