N,N'-(2,2'-(ethyne-1,2-diyl)bis(2,1-phenylene))bis(4-methylbenzenesulfonamide)

Base Information

Chemical Name:N,N'-(2,2'-(ethyne-1,2-diyl)bis(2,1-phenylene))bis(4-methylbenzenesulfonamide)
CAS No.:131298-22-1
Molecular Formula:C₂₈H₂₄N₂O₄S₂
Molecular Weight:516.642
Hs Code.:

Synonyms:N,N'-(2,2'-(ethyne-1,2-diyl)bis(2,1-phenylene))bis(4-methylbenzenesulfonamide)

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Chemical Property of N,N'-(2,2'-(ethyne-1,2-diyl)bis(2,1-phenylene))bis(4-methylbenzenesulfonamide)

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Technology Process of N,N'-(2,2'-(ethyne-1,2-diyl)bis(2,1-phenylene))bis(4-methylbenzenesulfonamide)

There total 5 articles about N,N'-(2,2'-(ethyne-1,2-diyl)bis(2,1-phenylene))bis(4-methylbenzenesulfonamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 131298-21-0
2-[(2-aminophenyl)ethynyl]phenylamine

: 131298-22-1
N,N'-(2,2'-(ethyne-1,2-diyl)bis(2,1-phenylene))bis(4-methylbenzenesulfonamide)

Guidance literature:: With pyridine; p-toluenesulfonyl chloride; at 20 ℃; for 4h;
DOI:10.1002/adsc.201200469

Reference yield: 80.0%

: 52670-38-9
2-ethynylaniline

: 61613-20-5
N-tosyl-2-iodoaniline

: 98-59-9
p-toluenesulfonyl chloride

: 131298-22-1
N,N'-(2,2'-(ethyne-1,2-diyl)bis(2,1-phenylene))bis(4-methylbenzenesulfonamide)

Guidance literature:: N-tosyl-2-iodoaniline; With bis-triphenylphosphine-palladium(II) chloride; triethylamine; for 0.25h;

2-ethynylaniline; With copper(l) iodide; at 20 ℃;

p-toluenesulfonyl chloride; With pyridine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1002/cjoc.202000701

Reference yield:

: 52670-38-9
2-ethynylaniline

: 131298-22-1
N,N'-(2,2'-(ethyne-1,2-diyl)bis(2,1-phenylene))bis(4-methylbenzenesulfonamide)

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / Inert atmosphere

2: dmap; pyridine / dichloromethane / Inert atmosphere

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; dichloromethane; 1: |Sonogashira Cross-Coupling;
DOI:10.1002/jhet.2333